Evidence map›Paper›PMID 37274524›Full record

ArticleOpen forum infectious diseases2023

Characterization of Typhoid Intestinal Perforation in Africa: Results From the Severe Typhoid Fever Surveillance in Africa Program.

Megan Birkhold, Shrimati Datta, Gi Deok Pak, Justin Im, Olakayode O Ogundoyin, Dare I Olulana, Taiwo A Lawal, Oludolapo O Afuwape, Aderemi Kehinde, Marie-France Phoba and 25 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

35 authors at 11 institutions in 11 countries.

Megan BirkholdCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-5746-1321
Shrimati DattaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Gi Deok PakEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.
Justin ImEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-3762-084X
Olakayode O OgundoyinDivision of Pediatric Surgery, University College Hospital and Department of Surgery, University of Ibadan, Ibadan, Nigeria.
Dare I OlulanaDivision of Pediatric Surgery, University College Hospital and Department of Surgery, University of Ibadan, Ibadan, Nigeria.
Taiwo A LawalDivision of Pediatric Surgery, University College Hospital and Department of Surgery, University of Ibadan, Ibadan, Nigeria.
Oludolapo O AfuwapeDivision of Gastrointestinal Surgery, University College Hospital and Department of Surgery, University of Ibadan, Ibadan, Nigeria.
Aderemi KehindeDepartment of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Marie-France PhobaDepartment of Microbiology, Institut National de Recherche Biomedicales, Kinshasa, Democratic Republic of Congo.
Gaëlle NkojiDepartment of Microbiology, Institut National de Recherche Biomedicales, Kinshasa, Democratic Republic of Congo.
Abraham AseffaArmauer Hansen Research Institute, ALERT Campus, Addis Ababa, Ethiopia.
Mekonnen TeferiArmauer Hansen Research Institute, ALERT Campus, Addis Ababa, Ethiopia.
Biruk YeshitelaArmauer Hansen Research Institute, ALERT Campus, Addis Ababa, Ethiopia.
Oluwafemi PopoolaDepartment of Community Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Michael OwusuDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Lady Rosny Wandji NanaInstitut Supérieur des Sciences de la Population, Université Joseph Ki Zerbo, Ouagadougou, Burkina Faso.
Enoch G CakpoInstitut Supérieur des Sciences de la Population, Université Joseph Ki Zerbo, Ouagadougou, Burkina Faso.
Moussa OuedraogoLaboratorie d'Analyses Medicales, Hopital Protestant Schiphra, Ouagadougou, Burkina Faso.
Edgar OuangreService de Chirurgie Viscérale, Hopital Yalgado, Ouagadougou, Burkina Faso.
Isso OuedraogoPediatric Department, Hopital Charles de Gaulle, Ouagadougou, Burkina Faso.
Anne-Sophie HeroesDepartment of Tropical Bacteriology, Institute of Tropical Medicine, Antwerp, Belgium.
Jan JacobsDepartment of Tropical Bacteriology, Institute of Tropical Medicine, Antwerp, Belgium.
Ondari D MogeniEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.
Andrea HaselbeckEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.
Leah SukriCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kathleen M NeuzilCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Octavie Lunguya MetilaDepartment of Microbiology, Institut National de Recherche Biomedicales, Kinshasa, Democratic Republic of Congo.
Ellis Owusu-DaboDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Yaw Adu-SarkodieDepartment of Medical Diagnostics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Abdramane Soura BassiahiInstitut Supérieur des Sciences de la Population, Université Joseph Ki Zerbo, Ouagadougou, Burkina Faso.
Raphaël RakotozandrindrainyDepartment of Microbiology and Parasitology, University of Antananarivo, Antananarivo, Madagascar.
Iruka N OkekeFaculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.ORCID https://orcid.org/0000-0002-1694-7587
Raphaël M ZellwegerEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.
Florian MarksEpidemiology, Public Health, and Impact Unit (EPIC), International Vaccine Institute, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-6043-7170
University of Ibadan · NGInternational Vaccine Institute · KRUniversity of Maryland, Baltimore · USAll Africa Leprosy Tuberculosis and Rehabilitation Training Centre · ETInstitut Superieur Des Sciences De La Population · BFKwame Nkrumah University of Science and Technology · GHInstituut voor Tropische Geneeskunde · BENational Institute of Biomedical Research · CDCentre Hospitalier Universitaire Yalgado Ouédraogo · BFUniversity of Antananarivo · MGUniversity of Kinshasa · CD

Funding

Medical Research Council MR/L00464X/1
6 · The paper itself

Abstract

Background: Typhoid intestinal perforation (TIP) remains the most serious complication of typhoid fever. In many countries, the diagnosis of TIP relies on intraoperative identification, as blood culture and pathology capacity remain limited. As a result, many cases of TIP may not be reported as typhoid. This study demonstrates the burden of TIP in sites in Burkina Faso, Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria. Methods: Patients with clinical suspicion of nontraumatic intestinal perforation were enrolled and demographic details, clinical findings, surgical records, blood cultures, tissue biopsies, and peritoneal fluid were collected. Participants were then classified as having confirmed TIP, probable TIP, possible TIP, or clinical intestinal perforation based on surgical descriptions and cultures. Results: A total of 608 participants were investigated for nontraumatic intestinal perforation; 214 (35%) participants had surgically-confirmed TIP and 33 participants (5%) had culture-confirmed typhoid. The overall proportion of blood or surgical site Conclusions: Low

Indexed as

Africaintestinal perforationSalmonella Typhisevere typhoidtyphoid fever

Identifiers

PMID37274524
PMCPMC10236516
OpenAlexW4379184469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.