Evidence map›Paper›PMID 37274265›Full record

ArticleFrontiers in oncology2023

Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage

Jonathan W Goldman, Lynette M Sholl, Sanja Dacic, Michael C Fishbein, Yonina R Murciano-Goroff, Ravi Rajaram, Sylwia Szymczak, Anna M Szpurka, Bo H Chao, Alexander Drilon

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Jonathan W GoldmanDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Lynette M ShollDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Sanja DacicDepartment of Pathology, Yale School of Medicine, New Haven, CT, United States.
Michael C FishbeinDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Yonina R Murciano-GoroffDepartment of Medicine, Memorial Sloan-Kettering Cancer Center New York, NY, United States.
Ravi RajaramDepartment of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Sylwia SzymczakLoxo@Lilly, Eli Lilly and Company, Warsaw, Poland.
Anna M SzpurkaLoxo@Lilly, Eli Lilly and Company, Indianapolis, IN, United States.
Bo H ChaoLoxo@Lilly, Eli Lilly and Company, New York, NY, United States.
Alexander DrilonDepartment of Medicine, Memorial Sloan-Kettering Cancer Center New York, NY, United States.
Eli Lilly (United States) · USUniversity of California, Los Angeles · USCornell University · USHarvard University · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USYale University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Predicting sensitivity and resistance in RET-driven cancersR01CA251591 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DRILON, ALEXANDER · 2021 to 2025
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA251591
6 · The paper itself

Abstract

The LIBRETTO-001 trial demonstrated the activity of the selective rearrangement during transfection (RET) inhibitor selpercatinib in advanced

Indexed as

case reportmajor pathologic responseneoadjuvantNSCLCpathologic complete responseRET fusionselective RET inhibitor

Identifiers

PMID37274265
PMCPMC10232990
OpenAlexW4377023314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.