Evidence map›Paper›PMID 37274190›Full record

ArticleFrontiers in neuroscience2023

David D Au, Jenny C Liu, Soo Jee Park, Thanh H Nguyen, Mia Dimalanta, Alexander J Foden, Todd C Holmes

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Differential regulation of sleep by blue, green, and red light inFrontiers in behavioral neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

David D AuDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Jenny C LiuDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Soo Jee ParkDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Thanh H NguyenDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Mia DimalantaDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Alexander J FodenDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Todd C HolmesDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · US

Funding

UV to blue neuronal phototransduction mechanismsR35GM127102 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Todd C Holmes · 2018 to 2026
$4.4M
NIGMS NIH HHS R35 GM127102
6 · The paper itself

Abstract

Lateral ventral neurons (LNvs) in the fly circadian neural circuit mediate behaviors other than clock resetting, including light-activated acute arousal. Converging sensory inputs often confer functional redundancy. The LNvs have three distinct light input pathways: (1) cell autonomously expressed cryptochrome (CRY), (2) rhodopsin 7 (Rh7), and (3) synaptic inputs from the eyes and other external photoreceptors that express opsins and CRY. We explored the relative photoelectrical and behavioral input contributions of these three photoreceptor systems to determine their functional impact in flies. Patch-clamp electrophysiology measuring light evoked firing frequency (FF) was performed on large LNvs (l-LNvs) in response to UV (365 nm), violet (405 nm), blue (450 nm), or red (635 nm) LED light stimulation, testing controls versus mutants that lack photoreceptor inputs

Indexed as

cryptochromeDrosophila melanogasterelectrophysiologyexternal rhodopsininternal rhodopsin-7light arousal behaviornon-image forming visionphotoreceptor circuit

Identifiers

PMID37274190
PMCPMC10235467
OpenAlexW4377097897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.