Evidence map›Paper›PMID 37273999›Full record

ArticleInternational journal of bioprinting2023

The biological properties of 3D-printed degradable magnesium alloy WE43 porous scaffolds via the oxidative heat strategy.

Shuyuan Min, Chaoxin Wang, Bingchuan Liu, Jinge Liu, Yu Liu, Zehao Jing, Yan Cheng, Peng Wen, Xing Wang, Yufeng Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Advances in biodegradable medical magnesium alloys for orthopedic applications].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuyuan MinDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.
Chaoxin WangDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.
Bingchuan LiuDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.
Jinge LiuDepartment of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Yu LiuDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.
Zehao JingDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.
Yan ChengBiomed-X Center, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
Peng WenDepartment of Mechanical Engineering, Tsinghua University, Beijing, 100084, China.
Xing WangBeijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Yufeng ZhengSchool of Materials Science and Engineering, Peking University, Beijing, 100871, China.
Yun TianDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a biodegradable material, magnesium alloy has a modulus similar to that of bone, and given the biological activity of its degradation products, it has the potential to be a bone grafting material. Oxidation heat treatment is a very effective passivation method that may reduce the rate of magnesium alloy degradation. Oxidation heat treatment increases the rare earth oxide content of the scaffold as well as the corrosion resistance of the scaffold. The overall cytotoxicity of the as-printed scaffolds (APSs) and oxidation heat-treated scaffolds (OHSs) showed that OHSs accelerated cell proliferation. In the apoptosis experiment, the OHS group had a cell survival rate between that of the control group and of the as-printed group. In the osteogenic induction experiment, the alkaline phosphatase activity and the quantity of mineralized nodules were greater in the APS and OHS groups than in the control group. Marker proteins for bone growth were expressed at higher levels in the APS and OHS groups than in the control group. Therefore, oxidation heat-treated 3D printing scaffolds with good biocompatibility and osteogenic properties have great potential to be made into advanced biomaterials that can be used to fix bone defects.

Indexed as

3D printingBone graftMagnesium alloyOxidation heatWE43 alloy

Identifiers

PMID37273999
PMCPMC10236336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.