ReviewStructural heart : the journal of the Heart Team2023
Secondary Mitral Regurgitation: Cardiac Remodeling, Diagnosis, and Management.
Review in Structural heart : the journal of the Heart Team, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Pooled it
- Long-term hemodynamic responses and reverse remodeling after pharmacotherapy in HFpEF versus HFrEF: a systematic review and meta-analysis.American journal of physiology. Heart and circulatory physiology · 2025Pooled it
- Cardiac remodelling and clinical outcomes after mitral edge-to-edge repair with the PASCAL® system.European heart journal. Imaging methods and practice · 2026Article
- The Expanding Therapeutic Armamentarium for Mitral Regurgitation: Surgical and Transcatheter Interventions.Biomedicines · 2026Review
- Linking patent foramen ovale with atrial cardiomyopathy: a narrative review of clinical signals, electrophysiology, and translational opportunities.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Left ventricular reverse remodelling after mitral transcatheter edge-to-edge repair: results from the EXPANDed studies.ESC heart failure · 2026Article
- Atrial Secondary Mitral Regurgitation: Pathophysiology, Diagnosis, and Surgical Implications.Medicina (Kaunas, Lithuania) · 2026Review
- Hypertension and Valvular Heart Disease: An Overview of a Complex and Clinically Meaningful Relationship.Life (Basel, Switzerland) · 2026Review
- The Carillon device in the treatment of patients with functional mitral regurgitation.Future cardiology · 2026Review
- Role of 3D left ventricular end-systolic volume in risk stratification and outcome prediction in significant mitral regurgitation.European heart journal. Imaging methods and practice · 2026Article
- Technologies in minimally invasive treatment of severe mitral regurgitation.Cardiology journal · 2026Review
- Temporal trends in characteristics and outcomes of patients undergoing percutaneous mitral valve repair.World journal of cardiology · 2025Article
- A predictive model for the treatment outcomes of patients with secondary mitral regurgitation based on machine learning and model interpretation.BMC medical informatics and decision making · 2025Article
- Cardiac resynchronization therapy optimization by targeting papillary muscle dyssynchrony: A case report.HeartRhythm case reports · 2025Article
- Finite Element Modeling in Left Ventricular Cardiac Biomechanics: From Computational Tool to Clinical Practice.Bioengineering (Basel, Switzerland) · 2025Review
- Diagnosis and Diagnostic Challenges of Secondary Mitral Regurgitation in the Era of Transcatheter Edge-to-Edge Repair of the Mitral Valve.Journal of clinical medicine · 2025Review
- The Mechanisms and Pathophysiology of Mitral Regurgitation: A Narrative Review.Annals of cardiac anaesthesia · 2025Review
- Long-Term Outcomes of Mitral Valve Repair Versus Replacement in Patients with Ischemic Mitral Regurgitation: A Retrospective Propensity-Matched Analysis.Journal of cardiovascular development and disease · 2025Article
- Percutaneous Coronary Intervention as a Non-Surgical Treatment for Ischemic Mitral Regurgitation in Patients with Multi-Vessel Coronary Artery Disease.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Disparities in Mitral Valve Disease Associated with Heart Failure.Reviews in cardiovascular medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secondary mitral regurgitation (MR) refers to MR resulting from left ventricular or left atrial remodeling. In ischemic or nonischemic cardiomyopathy, left ventricular dilation (regional or global) leads to papillary muscle displacement, tethering, and leaflet malcoaptation. In atrial functional MR, MR occurs in patients with left atrial dilation and altered mitral annular geometry due to atrial fibrillation. In addition to cardiac remodeling, leaflet remodeling is increasingly recognized. Mitral leaflet tissue actively adapts through leaflet growth to ensure adequate coaptation. Leaflets, however, can also undergo maladaptive thickening and fibrosis, leading to increased stiffness. The balance of cardiac and leaflet remodeling is a key determinant in the development of secondary MR. Clinical management starts with detection, severity grading, and identification of the underlying mechanism, which relies heavily on echocardiography. Treatment of secondary MR consists of guideline-directed medical therapy, surgical repair or replacement, and transcatheter edge-to-edge repair. Based on a better understanding of pathophysiology, novel percutaneous mitral repair and replacement devices have been developed and clinical trials are underway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.