Evidence map›Paper›PMID 37273856›Full record

ArticleStructural heart : the journal of the Heart Team2023

Cardiac Computed Tomography Angiography Anatomical Characterization of Patients Screened for a Dedicated Transfemoral Transcatheter Valve System for Primary Aortic Regurgitation.

Shawnbir Gogia, Torsten P Vahl, Vinod H Thourani, Pradeep K Yadav, Isaac George, Susheel K Kodali, Nadira Hamid, Lauren Ranard, Tiffany Chen, Mitsuaki Matsumura and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structural heart : the journal of the Heart Team, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Outcomes of transcatheter aortic valve implantation for native aortic valve regurgitation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 14 institutions in 2 countries.

Shawnbir GogiaStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Torsten P VahlStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Vinod H ThouraniPiedmont Heart Institute, Atlanta, Georgia, USA.
Pradeep K YadavPiedmont Heart Institute, Atlanta, Georgia, USA.
Isaac GeorgeStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Susheel K KodaliStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Nadira HamidMinneapolis Heart Institute, Minneapolis, Minnesota, USA.
Lauren RanardStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Tiffany ChenDivision of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mitsuaki MatsumuraCardiovascular Research Foundation, New York, New York, USA.
Akiko MaeharaCardiovascular Research Foundation, New York, New York, USA.
Hendrik TreedeDepartment of Cardiac Surgery, University Hospital Bonn, Bonn, Germany.
Stephan BaldusDepartment of Internal Medicine and Cardiology, University Heart Center, Cologne, Germany.
David DanielsCalifornia Pacific Medical Center, San Francisco, California, USA.
Brett C SheridanCalifornia Pacific Medical Center, San Francisco, California, USA.
Firas ZahrDivision of Cardiovascular Medicine, Oregon Health Sciences University, Portland, Oregon, USA.
Mark J RussoDepartment of Cardiac Surgery, Robert Wood Johnson Hospital, New Brunswick, New Jersey, USA.
James M McCabeDivision of Cardiology, University of Washington, Seattle, Washington, USA.
Stanley J ChetcutiDivision of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Martin B LeonStructural Heart and Valve Center, Columbia University Medical Center, New York, New York, USA.
Raj R MakkarSmidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.
Omar K KhaliqueDivision of Cardiovascular Imaging, Saint Francis Hospital and Catholic Health, Roslyn, New York, USA.
Columbia University Irving Medical Center · USCalifornia Pacific Medical Center · USCardiovascular Research Foundation · USPiedmont Atlanta Hospital · USCedars-Sinai Medical Center · USMinneapolis Heart Institute Foundation · USOregon Health & Science University · USRobert Wood Johnson University Hospital · USSaint Francis Hospital · USUniversity Hospital Bonn · DEUniversity Hospital Cologne · DEUniversity of Michigan · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiac computed tomography angiography was used to identify anatomical characteristics of the aortic root in patients with severe aortic regurgitation (AR) as compared to those with aortic stenosis (AS) to judge feasibility of transcatheter aortic valve replacement (TAVR) with the JenaValve Trilogy system. Methods: Cardiac computed tomography angiography was performed prior to planned TAVR for 107 patients with severe AR and 92 patients with severe AS. Measurements related to aortic root and coronary artery anatomy were obtained and compared between groups. Perimeter >90 mm and aortic annulus angle ​>70 degrees were defined as the theoretical exclusion criteria for TAVR. A combination of sinus of Valsalva diameter <30 mm and coronary height <12 mm was defined as high risk for coronary occlusion. Results: The mean age of patients in the AR group was 74.9 ± 11.2 years, 46% were women, and the mean Society of Thoracic Surgeons risk score for mortality was 3.6 ± 2.1. Comparatively, the mean age of patients in the AS group was 82.3 ± 5.53 years, 65% were women, and the mean Society of Thoracic Surgeonsrisk score was 5.5 ± 3.3. Annulus area, perimeter, diameter, and angle were larger in patients with severe AR. Sinus of Valsalva diameters and heights were larger in patients with severe AR. More AR patients were excluded based on perimeter (14 vs. 2%) and annulus angle (6 vs. 1%). More AS patients exhibited high-risk anatomy for left main coronary occlusion (21 vs. 7%) and right coronary occlusion (14 vs. 3%). The maximum dimension of the ascending aorta was larger in patients with severe AR (39 vs. 35 mm). The percentage of referred AR patients with significant aortopathy requiring surgical intervention was very low (only 1 AR patient with ascending aorta diameter >5.5 cm). Conclusions: A significantly larger proportion of patients with severe AR are excluded from TAVR as compared to AS due to large aortic annulus size and steep annulus angulation. By far the most prevalent excluding factor is aortic annulus size, with fewer patients excluded due to angulation. AR patients have lower-risk anatomy for coronary occlusion. Larger transcatheter valve sizes and further delivery system modifications are required to treat a larger proportion of AR patients.

Indexed as

Aortic insufficiencyAortic stenosisAortic valveComputed tomographyTranscatheter aortic valve replacement

Identifiers

PMID37273856
PMCPMC10236804
OpenAlexW4323538644

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.