Evidence map›Paper›PMID 37273142›Full record

ArticleActa neurologica Belgica2023

Verification of propagation hypothesis in patients with sporadic hand onset amyotrophic lateral sclerosis.

Shintaro Iida, Tadashi Kanouchi, Takaaki Hattori, Kazuaki Kanai, Tomoko Nakazato, Nobutaka Hattori, Takanori Yokota

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Article in Acta neurologica Belgica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shintaro IidaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, Japan. shintaro.iid@gmail.com.ORCID http://orcid.org/0000-0003-4327-6448
Tadashi KanouchiDepartment of Laboratory Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Takaaki HattoriDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, Japan.
Kazuaki KanaiDepartment of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Tomoko NakazatoDepartment of Neurology, School of Medicine, Juntendo University, Tokyo, Japan.
Nobutaka HattoriDepartment of Neurology, School of Medicine, Juntendo University, Tokyo, Japan.
Takanori YokotaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, Japan.
Tokyo Medical and Dental University · JPJuntendo University · JPFukushima Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIf lesions in sporadic amyotrophic lateral sclerosis (ALS) originate from a single focal onset site and spread contiguously by prion-like cell-to-cell propagation at a constant speed, the lesion spread time should be proportional to the anatomical distance. We verify this model in the patients.

methodsIn 29 sporadic ALS patients with hand onset followed by spread to shoulder and leg, we retrospectively evaluated the inter/intra-regional spread time ratio: time interval of symptoms from hand-to-leg divided by that from hand-to-shoulder. We also obtained the corresponding inter-/intra-regional distance ratios of spinal cord from magnetic resonance imaging of 12 patients, and those of primary motor cortex from coordinates using neuroimaging software.

resultsInter-/intra-regional spread time ratios ranged from 0.29 to 6.00 (median 1.20). Distance ratios ranged from 1.85 to 2.86 in primary motor cortex and from 5.79 to 8.67 in spinal cord. Taken together with clinical manifestations, of 27 patients with the requisite information available, lesion spreading was consistent with the model in primary motor cortex in 4 (14.8%) patients, and in spinal cord in only 1 (3.7%) patient. However, in more patients (12 of 29 patients: 41.4%), the inter-regional spread times in a long anatomical distance of hand-to-leg were shorter than or equal to the intra-regional spread times in a short anatomical distance of hand-to-shoulder.

conclusionContiguous cell-to-cell propagation at a constant speed might not play a major role at least in distant lesion spreading of ALS. Several mechanisms can be responsible for progression in ALS.

Indexed as

Amyotrophic Lateral SclerosisHandHumansRetrospective StudiesAmyotrophic lateral sclerosisAnatomical distance of spreadCell-to-cell propagationNetwork propagationSymptom spread time

Identifiers

PMID37273142
OpenAlexW4379375478

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.