Evidence map›Paper›PMID 37273103›Full record

ArticleEJNMMI research2023

Targeted imaging of very late antigen-4 for noninvasive assessment of lung inflammation-fibrosis axis.

Qin Zhu, Clayton E Barnes, Philip Z Mannes, Joseph D Latoche, Kathryn E Day, Jessie R Nedrow, Enrico M Novelli, Carolyn J Anderson, Sina Tavakoli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qin Zhu *Department of Radiology, University of Pittsburgh, UPMC Presbyterian Hospital, 200 Lothrop Street, Suite E200, Pittsburgh, PA, 15213, USA.
Clayton E Barnes *Department of Radiology, University of Pittsburgh, UPMC Presbyterian Hospital, 200 Lothrop Street, Suite E200, Pittsburgh, PA, 15213, USA.
Philip Z MannesDepartment of Radiology, University of Pittsburgh, UPMC Presbyterian Hospital, 200 Lothrop Street, Suite E200, Pittsburgh, PA, 15213, USA.
Joseph D LatocheDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kathryn E DayDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jessie R NedrowDepartment of Radiology, University of Pittsburgh, UPMC Presbyterian Hospital, 200 Lothrop Street, Suite E200, Pittsburgh, PA, 15213, USA.
Enrico M NovelliDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Carolyn J AndersonDepartment of Chemistry, University of Missouri, Columbia, MO, USA.
Sina TavakoliDepartment of Radiology, University of Pittsburgh, UPMC Presbyterian Hospital, 200 Lothrop Street, Suite E200, Pittsburgh, PA, 15213, USA. sit23@pitt.edu.ORCID http://orcid.org/0000-0003-0574-3914
University of Pittsburgh · USUniversity of Missouri · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
PET Imaging of Vaso-Occlussive Crisis in Sickle Cell DiseaseR01HL154629 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANDERSON, CAROLYN J., NOVELLI, ENRICO M · 2022 to 2025
$2.7M
A Molecular Imaging Approach to Immuno-Metabolic Characterization of Vessel Wall MacrophagesK08HL144911 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TAVAKOLI, SINA · 2019 to 2023
$813k
Molecular Imaging of the ChemR23-Chemerin Axis in Acute Lung InjuryF30HL158038 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANNES, PHILIP ZACHARY · 2021 to 2024
$209k
NCI NIH HHS P30 CA047904NHLBI NIH HHS F30 HL158038NHLBI NIH HHS K08 HL144911NHLBI NIH HHS R01 HL154629
6 · The paper itself

Abstract

backgroundThe lack of noninvasive methods for assessment of dysregulated inflammation as a major driver of fibrosis (i.e., inflammation-fibrosis axis) has been a major challenge to precision management of fibrotic lung diseases. Here, we determined the potential of very late antigen-4 (VLA-4)-targeted positron emission tomography (PET) to detect inflammation in a mouse model of bleomycin-induced fibrotic lung injury.

methodSingle time-point and longitudinal VLA-4-targeted PET was performed using a high-affinity peptidomimetic radiotracer,

resultsLung uptake of

conclusionsVLA-4-targeted PET allows for assessment of the inflammation-fibrosis axis and prediction of disease progression in a murine model. The potential of

Indexed as

InflammationLung fibrosisMolecular imagingPETVery late antigen-4

Identifiers

PMID37273103
PMCPMC10240482
OpenAlexW4379375407

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.