ArticleCell and tissue research2023
The larval midgut of Anopheles, Aedes, and Toxorhynchites mosquitoes (Diptera, Culicidae): a comparative approach in morphophysiology and evolution.
Article in Cell and tissue research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- The internal larval anatomy of two rodent bot fly species: Cuterebra fontinella (Diptera: Oestridae) and Cuterebra americana.Journal of medical entomology · 2026Article
- Morphological Characterization of Abdominal Neuromuscular System of Aedes aegypti Larvae.The Journal of comparative neurology · 2026Article
- Discovery of an aquaporin (CrAQP2) in the freshwater larval midge,Current research in insect science · 2026Article
- Encapsulation of Beauveria bassiana conidia as a new strategy for the biological control of Aedes aegypti larvae.Scientific reports · 2024Article
- Exploring the midgut physiology of the non-haematophagous mosquitoOpen biology · 2024Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The mosquito larval midgut is responsible for acquiring and storing most of the nutrients that will sustain the events of metamorphosis and the insect's adult life. Despite its importance, the basic biology of this larval organ is poorly understood. To help fill this gap, we carried out a comparative morphophysiological investigation of three larval midgut regions (gastric caeca, anterior midgut, and posterior midgut) of phylogenetically distant mosquitoes: Anopheles gambiae (Anopheles albimanus was occasionally used as an alternate), Aedes aegypti, and Toxorhynchites theobaldi. Larvae of Toxorhynchites mosquitoes are predacious, in contrast to the other two species, that are detritivorous. In this work, we show that the larval gut of the three species shares basic histological characteristics, but differ in other aspects. The lipid and carbohydrate metabolism of the An. gambiae larval midgut is different compared with that of Ae. aegypti and Tx. theobaldi. The gastric caecum is the most variable region, with differences probably related to the chemical composition of the diet. The peritrophic matrix is morphologically similar in the three species, and processes involved in the post-embryonic development of the organ, such as cell differentiation and proliferation, were also similar. FMRF-positive enteroendocrine cells are grouped in the posterior midgut of Tx. theobaldi, but individualized in An. gambiae and Ae. aegypti. We hypothesize that Tx. theobaldi larval predation is an ancestral condition in mosquito evolution.
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