ArticleJournal of clinical microbiology2023
Getting the Most Out of Your Genome-Wide Association Study Using Polygenic Risk Scores.
Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Determining the risk of a phenotypic outcome is a complex balance of variants "for" or "against" the phenotype, which in the context of human genetic diseases have been summarized using polygenic risk scores. In a previously published article (K. T. Hellmann, L. Challagundla, B. M. Gray, D. A. Robinson, J Clin Microbiol 61:e01412-22, 2023, https://doi.org/10.1128/jcm.01412-22), Hellmann and colleagues demonstrate how the use of a bacterial polygenic risk score to predict S. epidermidis infection versus colonization in neonates led to both increases in predictive accuracy and improved generalizability to external data.
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