Evidence map›Paper›PMID 37272820›Full record

ArticleMicrobiology spectrum2023

Gallium Nitrate Enhances Antimicrobial Activity of Colistin against Klebsiella pneumoniae by Inducing Reactive Oxygen Species Accumulation.

Mingjuan Guo, Ping Tian, Qingqing Li, Bao Meng, Yuting Ding, Yanyan Liu, Yasheng Li, Liang Yu, Jiabin Li

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polyphenolic compounds inFrontiers in pharmacology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Matrine Restores Colistin Efficacy AgainstMolecules (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Nicorandil reduces the antimicrobial effectiveness of polymyxin E againstFrontiers in cellular and infection microbiology · 2025
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mingjuan Guo *Department of Infectious Disease, The Chaohu Affiliated Hospital of Anhui Medical University, Hefei, China.
Ping TianDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Qingqing LiDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Bao MengDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yuting DingDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yanyan LiuDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yasheng LiDepartment of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Liang Yu *Department of Infectious Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jiabin LiDepartment of Infectious Disease, The Chaohu Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-6539-1802
Anhui Medical University · CNChaohu Hospital of Anhui Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klebsiella pneumoniae, a pathogen of critical clinical concern, urgently demands effective therapeutic options owing to its drug resistance. Polymyxins are increasingly regarded as a last-line therapeutic option for the treatment of multidrug-resistant (MDR) Gram-negative bacterial infections. However, polymyxin resistance in K. pneumoniae is an emerging issue. Here, we report that gallium nitrate (GaNt), an antimicrobial candidate, exhibits a potentiating effect on colistin against MDR K. pneumoniae clinical isolates. To further confirm this, we investigated the efficacy of combined GaNt and colistin

Indexed as

Anti-Infective AgentsKlebsiella InfectionsAnimalsAnti-Bacterial AgentsAntioxidantsColistinDrug Resistance, Multiple, BacterialGalliumKlebsiella pneumoniaeMiceMicrobial Sensitivity TestsPolymyxinsReactive Oxygen SpeciesAnti-Bacterial AgentsAnti-Infective AgentsAntioxidantsColistinGalliumgallium nitratePolymyxinsReactive Oxygen Speciesbacterial antioxidant activitycolistingalliumKlebsiella pneumoniaeoxidative stressreactive oxygen species

Identifiers

PMID37272820
PMCPMC10434156
OpenAlexW4379375366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.