Evidence map›Paper›PMID 37272618›Full record

ArticleeLife2023

Haploinsufficiency of the essential gene

Virginia Folgado-Marco, Kristina Ames, Jacky Chuen, Kira Gritsman, Nicholas E Baker

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Virginia Folgado-Marco *Department of Genetics, Albert Einstein College of Medicine, Bronx, United States.
Kristina Ames *Department of Medical Oncology, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0002-6845-0898
Jacky ChuenDepartment of Genetics, Albert Einstein College of Medicine, Bronx, United States.
Kira GritsmanDepartment of Medical Oncology, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0002-1367-1167
Nicholas E BakerDepartment of Genetics, Albert Einstein College of Medicine, Bronx, United States.ORCID 0000-0002-4250-3488
Albert Einstein College of Medicine · US

Funding

Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA programK12GM102779 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Dianne Cox, Johanna Patricia Daily · 2012 to 2026
$9.2M
Cell Competition in Development and HomeostasisR01GM104213 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BAKER, NICHOLAS E · 2013 to 2022
$2.6M
PI3 Kinase Inactivation in Myelodysplastic SyndromeR01DK130895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GRITSMAN, KIRA · 2022 to 2025
$2.2M
PI3K Isoform Dependence in Adult Hematopoiesis and Myeloid LeukemiaR01CA196973 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GRITSMAN, KIRA · 2016 to 2020
$2.0M
Cytek Aurora Multiparameter Flow CytometerS10OD026833 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PORCELLI, STEVEN A · 2019 to 2019
$367k
Role of the Class IA PI3K in Hematopoietic Stem Cell Self-RenewalF32HL146119 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI AMES, KRISTINA · 2019 to 2022
$213k
PI3 Kinase Inactivation in Myelodysplastic SyndromeR56DK130895 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GRITSMAN, KIRA · 2021 to 2021
$100k
NCI NIH HHS R01 CA196973NHLBI NIH HHS F32 HL146119NIDDK NIH HHS R01 DK130895NIDDK NIH HHS R01DK130895NIDDK NIH HHS R56 DK130895NIDDK NIH HHS R56DK130895NIGMS NIH HHS IRACDA/BETTR training Institutional Research and Academic Career Development Award 2K12GH102779-07A1NIGMS NIH HHS K12 GM102779NIGMS NIH HHS R01 GM104213NIGMS NIH HHS R01GM104213NIH HHS 2K12GH102779NIH HHS F32HL146119NIH HHS R01CA196973NIH HHS S10 OD026833
6 · The paper itself

Abstract

Ribosomal protein (Rp) gene haploinsufficiency can result in Diamond-Blackfan Anemia (DBA), characterized by defective erythropoiesis and skeletal defects. Some mouse Rp mutations recapitulate DBA phenotypes, although others lack erythropoietic or skeletal defects. We generated a conditional knockout mouse to partially delete

Indexed as

Anemia, Diamond-BlackfanPancytopeniaAnimalsErythropoiesisGenes, EssentialHaploinsufficiencyHematopoietic Stem CellsMiceMice, KnockoutMitochondrial ProteinsRibosomal ProteinsMitochondrial Proteinsmitochondrial ribosomal protein S12Ribosomal Proteinsdevelopmental biologyerythropoiesishematopoiesishematopoietic stem cellmouseregenerative medicineribosomal proteinribosomopathyRpS12stem cells

Identifiers

PMID37272618
PMCPMC10287158
OpenAlexW4379376390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.