Evidence map›Paper›PMID 37272479›Full record

Trial reportThe British journal of nutrition2023

Effects of a low FODMAP diet on gut microbiota in individuals with treated coeliac disease having persistent gastrointestinal symptoms - a randomised controlled trial.

Anne Mari Herfindal, Frida van Megen, Mari K O Gilde, Jørgen Valeur, Knut Rudi, Gry I Skodje, Knut E A Lundin, Christine Henriksen, Siv Kjølsrud Bøhn

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03678935 (Effect of Fermentable Oligo-, di-, and Monosaccharides and Polyols), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03678935 nacompletednot on this map

Effect of Fermentable Oligo-, di-, and Monosaccharides and Polyols (FODMAP) Restriction on Persistent GI-symptoms in Coeliac Patients

TypeinterventionalSponsorOslo University HospitalRan2018 to 2025Enrolled80ConditionsCeliac Disease, Irritable Bowel Syndrome, Diet Modification, Gluten SensitivityArmsLow FODMAP diet
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anne Mari HerfindalDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0002-2268-180X
Frida van MegenKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.ORCID 0000-0001-7614-0016
Mari K O GildeDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway.
Jørgen ValeurUnger-Vetlesen Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.ORCID 0000-0001-7193-7069
Knut RudiDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0002-7809-3943
Gry I SkodjeHealthy Life Centre, Municipality of Nes, Nes, Norway.ORCID 0000-0002-6998-8614
Knut E A LundinKG Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway.ORCID 0000-0003-1713-5545
Christine HenriksenDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.ORCID 0000-0002-8079-8467
Siv Kjølsrud BøhnDepartment of Chemistry, Biotechnology and Food Sciences, Norwegian University of Life Sciences, Ås, Norway.ORCID 0000-0002-1131-0456

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individuals with coeliac disease (CeD) often experience gastrointestinal symptoms despite adherence to a gluten-free diet (GFD). While we recently showed that a diet low in fermentable oligo-, di-, monosaccharides and polyols (FODMAP) successfully provided symptom relief in GFD-treated CeD patients, there have been concerns that the low FODMAP diet (LFD) could adversely affect the gut microbiota. Our main objective was therefore to investigate whether the LFD affects the faecal microbiota and related variables of gut health. In a randomised controlled trial GFD-treated CeD adults, having persistent gastrointestinal symptoms, were randomised to either consume a combined LFD and GFD (

Indexed as

Celiac DiseaseGastrointestinal MicrobiomeIrritable Bowel SyndromeAdultDietDiet, Carbohydrate-RestrictedDiet, Gluten-FreeFermentationFODMAP DietHumansMonosaccharidesOligosaccharidesRNA, Ribosomal, 16SMonosaccharidesOligosaccharidesRNA, Ribosomal, 16SGut microbiotaLow FODMAP dietNeutrophil gelatinase-associated lipocalinShort-chain fatty acidsTreated coeliac disease

Identifiers

PMID37272479
PMCPMC10657752

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.