ArticleeLife2023
Role of the postinspiratory complex in regulating swallow-breathing coordination and other laryngeal behaviors.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of opioids and stimulants on the respiratory system.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Modeling synaptic interactions between mammalian breathing and swallowing central pattern generators.Biological cybernetics · 2026Article
- Orofacial Central Pattern Generators: Neuroanatomical and Clinical Insights into Sensory, Motor, Emotional Integration.Experimental neurobiology · 2026Review
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- A motor thalamic site in humans that suppresses involuntary breathing without awareness.Journal of neurophysiology · 2026Article
- Mecp2 deficiency induces dysphagia in a preclinical model of Rett syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuroanatomical organization: the palato-pharyngeal complex as a sensory-motor hub.Frontiers in neuroanatomy · 2026Review
- High density probes reveal medullary seizure and rapid medullary shutdown in a model of fatal apnea in seizure.Epilepsy research · 2025Article
- Review
- The Potential Role of Oxidative Stress in Modulating Airway Defensive Reflexes.Antioxidants (Basel, Switzerland) · 2025Review
- Spatio-temporal segregation between sensory relay and swallowing pre-motor population activities by optical imaging in the rat nucleus of the solitary tract.Pflugers Archiv : European journal of physiology · 2025Article
- Neuroanatomical and neurochemical organization of brainstem and forebrain circuits involved in breathing regulation.Journal of neurophysiology · 2025Review
- Ndufs4 inactivation in glutamatergic neurons reveals swallow-breathing discoordination in a mouse model of Leigh syndrome.Experimental neurology · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
- Role of the KF/PBN in postinspiration.Journal of neurophysiology · 2025Article
- Activation of the periaqueductal gray controls respiratory output through a distributed brain network.Frontiers in physiology · 2025Article
- California mice (Peromyscus californicus) adjust mouth movements for vocal production during early postnatal development.BMC biology · 2024Article
- Afferent and Efferent Connections of the Postinspiratory Complex (PiCo) Revealed by AAV and Monosynaptic Rabies Viral Tracing.The Journal of comparative neurology · 2024Article
- Ndufs4 inactivation in glutamatergic neurons reveals swallow-breathing discoordination in a mouse model of Leigh Syndrome.bioRxiv : the preprint server for biology · 2024Article
- SubSol-HIe is an AMPK-dependent hypoxia-responsive subnucleus of the nucleus tractus solitarius that coordinates the hypoxic ventilatory response and protects against apnoea in mice.Pflugers Archiv : European journal of physiology · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Breathing needs to be tightly coordinated with upper airway behaviors, such as swallowing. Discoordination leads to aspiration pneumonia, the leading cause of death in neurodegenerative disease. Here, we study the role of the postinspiratory complex (PiCo) in coordinating breathing and swallowing. Using optogenetic approaches in freely breathing anesthetized ChATcre:Ai32, Vglut2cre:Ai32 and intersectional recombination of ChATcre:Vglut2FlpO:ChR2 mice reveals PiCo mediates airway protective behaviors. Activation of PiCo during inspiration or the beginning of postinspiration triggers swallow behavior in an all-or-nothing manner, while there is a higher probability for stimulating only laryngeal activation when activated further into expiration. Laryngeal activation is dependent on stimulation duration. Sufficient bilateral PiCo activation is necessary for preserving the physiological swallow motor sequence since activation of only a few PiCo neurons or unilateral activation leads to blurred upper airway behavioral responses. We believe PiCo acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing. Investigating PiCo's role in swallow and laryngeal coordination will aid in understanding discoordination with breathing in neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.