Evidence map›Paper›PMID 37272417›Full record

ArticleeLife2023

Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand.

Maura Greiser, Mariusz Karbowski, Aaron David Kaplan, Andrew Kyle Coleman, Nicolas Verhoeven, Carmen A Mannella, W Jonathan Lederer, Liron Boyman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. CaBiomolecules · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Maura Greiser *Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.ORCID 0000-0002-3197-0910
Mariusz Karbowski *Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Aaron David KaplanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Andrew Kyle ColemanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Nicolas VerhoevenCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Carmen A MannellaCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
W Jonathan LedererCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.
Liron BoymanCenter for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, United States.ORCID 0000-0002-4485-680X
University of Mary · USUniversity of Maryland, Baltimore · US

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Multiscale spatiotemporal modeling of cardiac mitochondriaU01HL116321 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAFRI, MOHSIN SALEET, LEDERER, WILLIAM JONATHAN · 2014 to 2018
$3.5M
Chemo-mechanical signaling in atrial myocytesR01HL142290 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEDERER, WILLIAM JONATHAN, WARD, CHRISTOPHER WILLIAM · 2019 to 2022
$2.6M
Extracellular miRNAs, innate immunity, and critical illnessR35GM140822 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI WEI CHAO · 2021 to 2026
$2.5M
Ubiquitin-dependent mitochondrial quality controlR01GM129584 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI KARBOWSKI, MARIUSZ · 2019 to 2022
$1.3M
NHLBI NIH HHS R01 HL142290NHLBI NIH HHS U01 HL116321NIAID NIH HHS U19 AI090959NIAMS NIH HHS T32 AR007592NIA NIH HHS P30 AG028747NIGMS NIH HHS R01 GM129584NIGMS NIH HHS R35 GM140822
6 · The paper itself

Abstract

Mitochondrial ATP production in ventricular cardiomyocytes must be continually adjusted to rapidly replenish the ATP consumed by the working heart. Two systems are known to be critical in this regulation: mitochondrial matrix Ca

Indexed as

CalciumCyclic AMPAdenosine TriphosphateAdenylyl CyclasesBicarbonatesCalcium, DietaryCalcium SignalingCarbon DioxideMyocytes, CardiacAdenosine TriphosphateAdenylyl CyclasesBicarbonatesCalciumCalcium, DietaryCarbon DioxideCyclic AMPbiochemistrycalciumcAMPchemical biologyheartmitochondrial ATP productionmolecular biophysicsratsoluble adenylyl cyclasestructural biologyventricular myocytes

Identifiers

PMID37272417
PMCPMC10284600
OpenAlexW4379375756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.