Evidence map›Paper›PMID 37272244›Full record

ArticleJournal of breast cancer2023

Anatomy Versus Physiology: Is Breast Lymphatic Drainage to the Internal Thoracic (Internal Mammary) Lymphatic System Clinically Relevant?

Priscilla Machado, Ji-Bin Liu, Laurence Needleman, Christine Lee, Flemming Forsberg

Open access · goldAbstract read
In one paragraph

Article in Journal of breast cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Priscilla MachadoDepartment of Radiology, Thomas Jefferson University, Philadelphia, USA. priscilla.machado@jefferson.edu.ORCID https://orcid.org/0000-0003-4107-2986
Ji-Bin LiuDepartment of Radiology, Thomas Jefferson University, Philadelphia, USA.ORCID https://orcid.org/0000-0003-2979-9162
Laurence NeedlemanDepartment of Radiology, Thomas Jefferson University, Philadelphia, USA.ORCID https://orcid.org/0000-0003-1683-4547
Christine LeeDepartment of Radiology, Mayo Clinic, Rochester, USA.ORCID https://orcid.org/0000-0001-5298-6949
Flemming ForsbergDepartment of Radiology, Thomas Jefferson University, Philadelphia, USA.ORCID https://orcid.org/0000-0003-2215-1371
Thomas Jefferson University · USMayo Clinic · US

Funding

Contrast Ultrasound Detection of Sentinel Lymph Nodes in Breast Cancer PatientsR01CA172336 · NCI · THOMAS JEFFERSON UNIVERSITY · PI FORSBERG, FLEMMING · 2015 to 2019
$1.2M
NCI NIH HHS R01 CA172336NIH HHS R01 CA172336
6 · The paper itself

Abstract

Approximately 15%-25% of breast lymphatic drainage passes through the internal thoracic (internal mammary) lymphatic system, draining the inner quadrants of the breast. This study aimed to use lymphosonography to identify sentinel lymph nodes (SLNs) in the axillary and internal thoracic lymphatic systems in patients with breast cancer. Seventy-nine patients received subcutaneous ultrasound contrast agent injections around the tumor. Lymphosonography was used to identify SLNs. In 14 of the 79 patients (17.7%), the tumor was located in the inner quadrant of the breast. Lymphosonography identified 217 SLNs in 79 patients, averaging 2.7 SLNs per patient. The 217 identified SLNs in the 79 patients were located in the axillary lymphatic system; none were located in the internal thoracic (internal mammary) lymphatic system, although it was expected in two to four patients (i.e., 4-11 SLNs). These results implied that SLNs associated with breast cancer are predominantly located in the axillary lymphatic system.

Indexed as

Breast NeoplasmsContrast MediaLymphatic SystemLymph NodesUltrasonography

Identifiers

PMID37272244
PMCPMC10315328
OpenAlexW4362684722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.