ArticleEuropean journal of neurology2025
Cognitive deficits in patients with peripheral vestibular dysfunction.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the effectiveness of immersive and non-immersive virtual reality in the treatment of vertigo in patients with peripheral vestibular dysfunction: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- The relationship between depression, falls, dizziness, and physical activity in geriatric individuals with BPPV.BMC geriatrics · 2026Article
- Liquid Chromatography-Mass Spectrometry-Based Molecular Profiling of Vertigoheel.International journal of molecular sciences · 2026Article
- Aerobic Exercise Promotes Hippocampal Neurogenesis and Ameliorates Cognitive Dysfunction Induced by Unilateral Labyrinthectomy.CNS neuroscience & therapeutics · 2026Article
- Quantifying Changes in Balance, Gait, Fall Risk, and Sensory Reweighting in Older Adults Following Multi-Session Electrical Vestibular Stimulation Therapy.Medical devices (Auckland, N.Z.) · 2026Article
- Cognitive performance, dizziness and tinnitus among adults with unilateral audiovestibular disorders.Frontiers in neurology · 2026Article
- Cognitive deficits in patients with peripheral vestibular dysfunction.European journal of neurology · 2025Article
- A clinical 3D pointing test differentiates spatial memory deficits in dementia and bilateral vestibular failure.BMC neurology · 2024Article
- Subjective spatial orientation discomfort is associated with decreased real-world spatial performance and lower cognitive function.Frontiers in neuroscience · 2024Article
- Neurological update: neuro-otology 2023.Journal of neurology · 2023Article
- Normal visuospatial function in unilateral vestibulopathy: on the challenge of group differences within normal reference data.Frontiers in neurology · 2023Article
- Interpreting the meaning of changes in hippocampal volume associated with vestibular loss.Frontiers in integrative neuroscience · 2023Article
- Cognitive impairment in patients with chronic unilateral vestibulopathy: A resting-state functional MRI study.Journal of Alzheimer's disease reportsArticle
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Authors and funding
9 authors.
Funding
Abstract
background and purposePrevious studies demonstrated cognitive deficits in patients with peripheral vestibulopathy (PVP) with dysfunction of spatial navigation and orientation, but also documented cognitive decline in nonspatial abilities. This study evaluates cognitive deficits in patients with unilateral vestibulopathy (UVP) as well as bilateral vestibulopathy (BVP) in multiple cognitive domains using common screening tests to reliably detect these deficits in clinical practice.
methodsThis prospective study compared patients with UVP and BVP to age- and sex-matched healthy controls (HC). Tests included the Alzheimer's Disease Assessment Scale (ADAS), Mini-Mental Status Examination (MMSE), Trail Making Test Part A and B, Clock Drawing Task, Executive Interview-25 (EXIT25), Dementia Detection (DemTect), and the Judgment of Line Orientation (JLO). The Montgomery-Åsberg Depression Rating Scale was used to control for depression. Videonystagmography objectively reconfirmed PVP. The Vertigo Symptoms Scale and the Dizziness Handicap Inventory were used to assess for symptom severity and restrictions of activities of daily living.
resultsEighty-one patients (65 UVP, 16 BVP) were compared to 55 HC. Patients showed impairment in ADAS, MMSE, DemTect, EXIT25, and JLO. No differences between UVP and BVP were detected. The relative risk (RR) estimates of developing cognitive deficits following PVP were increased. The RR for the ADAS was higher in BVP (RR = 4.91, 95% confidence interval [CI] = 1.87-12.9, p = 0.001) than in UVP (RR = 3.75, 95% CI = 1.65-8.51, p = 0.002), but was similar for the MMSE and DemTect between groups.
conclusionsPatients with PVP showed deficits in multiple cognitive domains including nonspatial cognitive abilities. Vestibulopathy could be a risk factor for the development of cognitive impairment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.