Evidence map›Paper›PMID 37272180›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2023

[Effect of procalcitonin on lipopolysaccharide-induced expression of nucleotide-binding oligomerization domain-like receptor protein 3 and caspase-1 in human umbilical vein endothelial cells].

Wen Jiang, Ding-Hua Shi, Yan-Juan He, Chun-Yuan Chen

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wen JiangDepartment of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Ding-Hua ShiDepartment of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Yan-Juan HeDepartment of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Chun-Yuan ChenDepartment of Pediatrics, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the effect of procalcitonin (PCT) on lipopolysaccharide (LPS)-induced expression of the pyroptosis-related proteins nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and caspase-1 in human umbilical vein endothelial cells (HUVECs).

methodsHUVECs were induced by LPS to establish a model of sepsis-induced inflammatory endothelial cell injury. The experiment was divided into two parts. In the first part, HUVECs were randomly divided into four groups: normal control, LPS (1 μg/mL), PCT (10 ng/mL), and LPS+PCT (

resultsIn the first experiment: compared with the normal control group, the PCT, LPS, and LPS+PCT groups had significantly upregulated mRNA and protein expression levels of NLRP3 and caspase-1 (

conclusionsLPS can promote the expression of the pyroptosis-related proteins NLRP3 and caspase-1 in HUVECs, while PCT can inhibit the LPS-induced expression of the pyroptosis-related proteins NLRP3 and caspase-1 in HUVECs in a concentration-dependent manner.

Indexed as

LipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinCaspase 1HumansHuman Umbilical Vein Endothelial CellsNucleotidesProcalcitoninCaspase 1LipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNucleotidesProcalcitoninCaspase-1Human umbilical vein endothelial cellNucleotide-binding oligomerization domain-like receptor protein 3ProcalcitoninPyroptosisSepsis

Identifiers

PMID37272180
PMCPMC10247201
OpenAlexW4379376548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.