ArticleThe Journal of pediatrics2023
Neurobehavioral and Medical Correlates of Autism Screening: 2-Year Outcomes for Infants Born Very Preterm.
Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Autism Screening Using Parent's Observations of Social Interactions (POSI) in High-Risk Infants.Journal of autism and developmental disorders · 2026Article
- Heart rate variability is associated with self-regulation and stress neurobehavior in preterm infants.Early human development · 2025Article
- Prenatal, Perinatal, and Postnatal Factors in a Cohort of Very Preterm and Very Low Birth Weight Toddlers with Suspected Autism Spectrum Disorder.Journal of autism and developmental disorders · 2025Article
- Motor developmental delay in preschoolers with autism spectrum disorders in China and its association with core symptoms and maternal risk factors: a multi-center survey.Child and adolescent psychiatry and mental health · 2025Article
- Developmental characteristics and accuracy of autism screening among two-year-old toddlers in the ECHO program.Pediatric research · 2024Article
- Neonatal neurobehavior associated with developmental changes from age 2 to 3 in very preterm infants.Early human development · 2024Article
- Clinical, socio-demographic, and parental correlates of early autism traits in a community cohort of toddlers.Scientific reports · 2024Article
- Two-Year Autism Risk Screening and 3-Year Developmental Outcomes in Very Preterm Infants.JAMA pediatrics · 2024Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectiveTo identify neonatal characteristics and 2-year neurodevelopmental outcomes associated with positive screening for risk of autism. STUDY
designNine university-affiliated neonatal intensive care units (NICUs) enrolled infants born at <30 weeks of gestation. Infants underwent the NICU Network Neurobehavioral Scale examination before discharge and the Bayley Scales of Infant and Toddler Development, Third Edition, the Child Behavior Checklist, and the Modified Checklist for Autism in Toddlers, revised with follow-up (M-CHAT-R/F) at 2 years of corrected age. Generalized estimating equations examined associations between M-CHAT-R/F, neurobehavioral test results, and neonatal medical morbidities.
resultsAt 2 years of corrected age, data were available for 466 of 744 enrolled infants without cerebral palsy. Infants with hypoaroused NICU Network Neurobehavioral Scale profiles were more likely to screen M-CHAT-R/F-positive (OR 2.76, 95% CI 1.38-5.54). Infants with ≥2 medical morbidities also were more likely to screen positive (OR 2.65, 95% CI 1.27-5.54). Children with positive M-CHAT-R/F scores had lower Bayley Scales of Infant and Toddler Development, Third Edition, Cognitive (t [451] = 5.43, P < .001, d = 0.82), Language (t [53.49] = 7.82, P < .001, d = 1.18), and Motor (t [451] = 7.98, P < .001, d = 1.21) composite scores and significantly greater Child Behavior Checklist Internalizing (t [457] -6.19, P < .001, d = -0.93) and Externalizing (t [57.87] = -5.62, P < .001, d = -0.84) scores.
conclusionsPositive M-CHAT-R/F screens at 2 years of corrected age were associated with neonatal medical morbidities and neurobehavioral examinations as well as toddler developmental and behavioral outcomes. These findings demonstrate the potential utility of the M-CHAT-R/F as a global developmental screener in infants born very preterm, regardless of whether there is a later autism diagnosis.
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