ArticleThe Annals of thoracic surgery2024
Outcomes of Lung Transplant Candidates Aged ≥70 Years During the Lung Allocation Score Era.
Article in The Annals of thoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Lung transplantation outcomes in candidates aged ≥ 70 years old: A 10-year single center experience.JHLT open · 2026Article
- Article
- Timing of quality of life and lung function changes during the first year following lung transplantation: A multicenter prospective cohort study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Observational
- Differential effects of donor factors on post-transplant survival in lung transplantation.JHLT open · 2024Article
- Risk factors for mid- and long-term mortality in lung transplant recipients aged 70 years and older.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- ERS International Congress 2023: highlights from the Thoracic Surgery and Lung Transplantation Assembly.ERJ open research · 2024Article
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10 authors.
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Abstract
backgroundWith the increasing age of lung transplant candidates, we studied waitlist and posttransplantation outcomes of candidates ≥70 years during the Lung Allocation Score era.
methodsAdult lung transplant candidates from 2005 to 2020 in the United Network for Organ Sharing database were included and stratified on the basis of age at listing into 18 to 59 years old, 60 to 69 years old, and ≥70 years old. Baseline characteristics, waitlist outcomes, and posttransplantation outcomes were assessed.
resultsA total of 37,623 candidates were included (52.3% aged 18-59 years, 40.6% aged 60-69 years, 7.1% aged ≥70 years). Candidates ≥70 years were more likely than younger candidates to receive a transplant (81.9% vs 72.7% [aged 60-69 years] vs 61.6% [aged 18-59 years]) and less likely to die or to deteriorate on the waitlist within 1 year (9.1% vs 10.1% [aged 60-69 years] vs 12.2% [aged 18-59 years]; P < .001). Donors for older recipients were more likely to be extended criteria (75.7% vs 70.1% [aged 60-69 years] vs 65.7% [aged 18-59 years]; P < .001). Recipients ≥70 years were found to have lower rates of acute rejection (6.7% vs 7.4% [aged 60-69 years] vs 9.2% [aged 18-59 years]; P < .001) and prolonged intubation (21.7% vs 27.4% [aged 60-69 years] vs 34.5% [aged 18-59 years]; P < .001). Recipients aged ≥70 years had increased 1-year (adjusted hazard ratio [aHR], 1.19 [95% CI, 1.06-1.33]; P < .001), 3-year (aHR, 1.28 [95% CI, 1.18-1.39]; P < .001), and 5-year mortality (aHR, 1.29 [95% CI, 1.21-1.38]; P < .001) compared with recipients aged 60 to 69 years.
conclusionsCandidates ≥70 years had favorable waitlist and perioperative outcomes despite increased use of extended criteria donors. Careful selection of candidates and postoperative surveillance may improve posttransplantation survival in this population.
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