ArticleThe lancet. Psychiatry2023
The association of alcohol dependence and consumption during adolescence with depression in young adulthood, in England: a prospective cohort study.
Article in The lancet. Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
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- Is there a bidirectional relationship between the number of unhealthy lifestyle factors and depressive symptoms in adolescents? Evidence from a longitudinal study.BMC medicine · 2026Article
- Young Adults Coping with Sibling Loss: Risk and Protective Factors for Substance Use Disorder.Journal of child & adolescent trauma · 2026Article
- Early Trajectory of Depressive Symptoms in Alcohol Dependence: Insights From a Four-Week Clinical Decision Window.Cureus · 2026Article
- Depression in Cape Verdean adolescents: prevalence and associated factors.BMC psychiatry · 2026Article
- The causal interplay between depression and alcohol use from adolescence to young adulthood: a Mendelian randomization study.Psychological medicine · 2026Article
- Associations of smartphone use duration and loneliness with depressive symptoms among Korean adolescents: a nationally representative cross-sectional study.Frontiers in public health · 2026Article
- Smartwatch-Based Ecological Momentary Assessment for High-Temporal-Density, Longitudinal Measurement of Alcohol Use (AlcoWatch): Feasibility Evaluation.JMIR formative research · 2025Article
- Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report.Genes, brain, and behavior · 2025Article
- Assessment of common mental disorders in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort at age 24 years using the Clinical Interview Schedule-Revised (CIS-R).Wellcome open research · 2025Article
- Changes in habits among mothers during the period of social isolation due to COVID-19 in the municipality of Rio Grande, Rio Grande do Sul, Brazil.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Article
- Influence of Drinking Context and Age of Onset on Alcohol Consumption Patterns and Motivations Among Uruguayan Adults.Sultan Qaboos University medical journal · 2024Article
- Socioeconomic disparities in alcohol-related depression: a national cohort study of low-income medical aid beneficiaries and national health insurance beneficiaries in Korea.BMC public health · 2024Article
- Risk of major depressive increases with increasing frequency of alcohol drinking: a bidirectional two-sample Mendelian randomization analysis.Frontiers in public health · 2024Article
- Pet Ownership, Living Alone, and Cognitive Decline Among Adults 50 Years and Older.JAMA network open · 2023Article
- Article
- Prevalence and associated factors of probable depression amongst pregnant and parenting young females: a comparison of adolescents and young adults in rural South Africa.Frontiers in child and adolescent psychiatry · 2023Article
- Mood instability and low back pain: a mendelian randomization study.Frontiers in neurology · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThe role of alcohol use in the development of depression is unclear. We aimed to investigate whether alcohol dependence, but not high frequency or quantity of consumption, during adolescence increased the risk of depression in young adulthood.
methodsIn this prospective cohort study, we included adolescents who were born to women recruited to the Avon Longitudinal Study of Parents and Children in Avon, UK, with delivery dates between April 1, 1991, and Dec 31, 1992. Alcohol dependence and consumption were measured at about age 16 years, 18 years, 19 years, 21 years, and 23 years using the self-reported Alcohol Use Disorders Identification Test, and at about age 18 years, 21 years, and 23 years using items corresponding to DSM-IV symptoms. The primary outcome was depression at age 24 years, assessed using the Clinical Interview Schedule Revised. Analyses were probit regressions between growth factors for alcohol dependence and consumption and depression, before and after adjustments for confounders: sex, housing tenure, maternal education, maternal depressive symptoms, parents' alcohol use, conduct problems at age 4 years, being bullied from age 12-16 years, and frequency of smoking cigarettes or cannabis. Adolescents were included in analyses if they had data from at least one timepoint for alcohol use and confounders.
findingsWe included 3902 adolescents (2264 [58·0%] female; 1638 [42·0%] male) in our analysis, and 3727 (96·7%) of 3853 participants with data on ethnicity were White. After adjustments, we found a positive association between alcohol dependence at 18 years of age (latent intercept) and depression at 24 years of age (probit coefficient 0·13 [95% CI 0·02 to 0·25]; p=0·019), but no association between rate of change (linear slope) and depression (0·10 [-0·82 to 1·01]; p=0·84). There was no evidence of an association between alcohol consumption and depression (latent intercept probit coefficient -0·01 [-0·06 to 0·03]; p=0·60; linear slope 0·01 [-0·40 to 0·42]; p=0·96) after adjustments.
interpretationPsychosocial or behavioural interventions that reduce the risk of alcohol dependence during adolescence could contribute to preventing depression in young adulthood.
fundingUK Medical Research Council and Alcohol Research UK (grant number MR/L022206/1).
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