Evidence map›Paper›PMID 37270935›Full record

ArticleDrug and alcohol dependence2023

Negative affect and craving during abstinence from smoking are both linked to default mode network connectivity.

Golnaz Tabibnia, Dara G Ghahremani, Jean-Baptiste F Pochon, Maylen Perez Diaz, Edythe D London

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Cue labeling reduces cigarette craving and associated neural activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. A Novel Therapeutic Mechanism for Nicotine Craving in Schizophrenia.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Golnaz TabibniaDepartment of Psychological Science, University of California, Irvine, CA, USA. Electronic address: tabibnia@uci.edu.
Dara G GhahremaniDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Jean-Baptiste F PochonDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Maylen Perez DiazDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
Edythe D LondonDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
University of California, Los Angeles · USUniversity of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Neural Substrates of Cigarette Craving, Withdrawal, and Relief: Male-Female DifferencesR37DA044467 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LONDON, EDYTHE DANICK · 2017 to 2022
$2.7M
Sex differences in glutamate and cigarette withdrawal states: a multimodal imaging studyF32DA049500 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PEREZ DIAZ, MAYLEN · 2020 to 2021
$134k
NCATS NIH HHS UL1 TR001414NIDA NIH HHS F32 DA049500NIDA NIH HHS R37 DA044467
6 · The paper itself

Abstract

backgroundNegative affect and craving during abstinence from cigarettes predict resumption of smoking. Therefore, understanding their neural substrates may guide development of new interventions. Negative affect and craving have traditionally been linked to functions of the brain's threat and reward networks, respectively. However, given the role of default mode network (DMN), particularly the posterior cingulate cortex (PCC), in self-related thought, we examined whether DMN activity underlies both craving and negative affective states in adults who smoke.

methods46 adults who smoke abstained from smoking overnight and underwent resting-state fMRI, after self-reporting their psychological symptoms (negative affect) and craving on the Shiffman-Jarvik Withdrawal Scale and state anxiety (negative affect) on the Spielberger State-Trait Anxiety Inventory. Within-DMN functional connectivity using 3 different anterior PCC seeds was tested for correlations with self-report measures. Additionally, independent component analysis with dual regression was performed to measure associations of self-report with whole-brain connectivity of the DMN component.

resultsCraving correlated positively with connectivity of all three anterior PCC seeds with posterior PCC clusters (p

conclusionsAlthough negative affect and craving are distinct subjective states, they appear to share a common neural pathway within the DMN, particularly involving the PCC.

Indexed as

CravingDefault Mode NetworkAdultAffectBrainBrain MappingGyrus CinguliHumansMagnetic Resonance ImagingNeural PathwaysSmokingBrain imagingDefault mode networkEmotionNicotineTobacco use disorderWithdrawal

Identifiers

PMID37270935
PMCPMC10516582
OpenAlexW4376619557

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.