ArticleAnnals of Saudi medicine
Association of intraoperative lactate elevation and postoperative mortality and morbidity in patients undergoing craniotomy: retrospective analysis.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Association between lactate-to-albumin ratio and clinical outcomes in perioperative patients with chronic kidney disease: a retrospective cohort study based on INSPIRE database.Clinical and experimental nephrology · 2026Article
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2 authors at 2 institutions in 1 country.
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Abstract
backgroundIntraoperative lactate levels increase in patients undergoing craniotomy, but the reason is not yet fully known. High levels of intraoperative lactate are associated with mortality and morbidity in patients with septic shock and abdominal and cardiac surgery.
objectivesInvestigate whether intraoperative lactate elevation is associated with postoperative systemic and neurological complications and mortality in craniotomy.
designRetrospective study
settingUniversity hospital in Turkey. PATIENTS AND
methodsIn this study, we included patients who underwent elective intracranial tumor surgery in our hospital between 1 January 2018, and 31 December 2018. According to the level of intraoperative lactate, patients were divided into two groups: high (≥2.1 mmol/L) and normal (<2.1 mmol/L). The groups were compared by the presence of postoperative new neurological deficits, postoperative surgical and medical complications, mechanical ventilation duration, 30-day mortality, in-hospital mortality, and hospital stay length. Cox regression analysis was performed for the 30-day mortality outcome.
main outcome measuresAssociation between intraoperative lactate levels and postoperative 30-day mortality. SAMPLE SIZE: 163 patients with lactate data.
resultsWhile no significant difference was found between the groups regarding age, gender, ASA score, tumor location, operation time and pathology results, preoperative neurologic deficits were higher in the high intraoperative lactate group (
conclusionIntraoperative lactate elevation was associated with postoperative 30-day mortality in patients undergoing craniotomy. The intraoperative level of lactate is an important mortality predictor in patients undergoing craniotomy. LIMITATIONS: Retrospective design and single-centered, missing most data for several variables. CONFLICT OF INTEREST: None.
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