ArticleActa obstetricia et gynecologica Scandinavica2023
Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow-up six months after birth.
Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the globally reported International Classification of Diseases to Perinatal Mortality (ICD-PM).Frontiers in medicine · 2024Pooled it
- Autonomous fetal morphology scan: deep learning + clustering merger - the second pair of eyes behind the doctor.BMC medical informatics and decision making · 2024Trial
- When Primary Ciliary Dyskinesia Is Diagnosed in Utero: Insights from Two Families.Advances in therapy · 2025Article
- Prevalence and trends of major congenital anomalies in Brazil: A study from 2011 to 2020.PloS one · 2025Article
- Article
- Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow-up six months after birth.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Prenatal Ultrasound Evaluation of Congenital Hand Anomalies: Toward a Standardized Approach.Journal of medical ultrasoundArticle
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4 authors.
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Abstract
introductionTo investigate the performance of the second-trimester ultrasound scan regarding ultrasound-detectable congenital malformations in a Danish region. The study sample was population-based, with 6 months of postnatal follow-up. Hospital records and autopsy reports were reviewed in each case to validate the prenatal ultrasound diagnosis. MATERIAL AND
methodsThis population-based cohort study included all fetuses (n = 19.367) alive at the second-trimester scan in four hospitals in a Danish region. The final diagnosis of the malformations was based on hospital records during the 6-month postnatal follow-up. In case of termination or stillbirth, the result from the autopsy report was used to validate the prenatal ultrasound diagnosis.
resultsThe detection rate of congenital malformations in the prenatal screening program was 69%, where 18% was detected on the first-trimester scan and 51% on the second-trimester scan. Another 8% was detected in the third trimester. Specificity was 99.9%. The positive predictive value of the screening program was 94.5%, and the negative predictive value was 99.5%. The overall prevalence of malformations was 16.8 per 1000 fetuses, most frequently in the heart and the urinary tract.
conclusionsThis study shows that the national screening program for congenital malformations can detect many severe malformations and is an effective screening test for malformations.
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