Evidence map›Paper›PMID 37270640›Full record

ReviewBiotechnology for biofuels and bioproducts2023

Production of short-chain fatty acids (SCFAs) as chemicals or substrates for microbes to obtain biochemicals.

Elia Tomás-Pejó, Cristina González-Fernández, Silvia Greses, Christian Kennes, Nuria Otero-Logilde, María C Veiga, David Bolzonella, Bettina Müller, Volkmar Passoth

Open access · goldAbstract readReview
In one paragraph

Review in Biotechnology for biofuels and bioproducts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Recent advances in microbial production of odd-chain fatty acids.World journal of microbiology & biotechnology · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. ChemSusChem · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Elia Tomás-PejóBiotechnological Processes Unit, IMDEA Energy, 28935, Móstoles, Madrid, Spain.
Cristina González-FernándezBiotechnological Processes Unit, IMDEA Energy, 28935, Móstoles, Madrid, Spain.
Silvia GresesBiotechnological Processes Unit, IMDEA Energy, 28935, Móstoles, Madrid, Spain.
Christian KennesChemical Engineering Laboratory, Faculty of Sciences and Center for Advanced Scientific Research, Centro de Investigaciones Científicas Avanzadas (CICA), BIOENGIN Group, University of La Coruña, E-15008, La Coruña, Spain.
Nuria Otero-LogildeChemical Engineering Laboratory, Faculty of Sciences and Center for Advanced Scientific Research, Centro de Investigaciones Científicas Avanzadas (CICA), BIOENGIN Group, University of La Coruña, E-15008, La Coruña, Spain.
María C VeigaChemical Engineering Laboratory, Faculty of Sciences and Center for Advanced Scientific Research, Centro de Investigaciones Científicas Avanzadas (CICA), BIOENGIN Group, University of La Coruña, E-15008, La Coruña, Spain.
David BolzonellaDepartment of Biotechnology, University of Verona, Verona, Italy.
Bettina MüllerDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Box 7070, 75007, Uppsala, Sweden.
Volkmar PassothDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Box 7070, 75007, Uppsala, Sweden. Volkmar.Passoth@slu.se.
Madrid Institute for Advanced Studies · ESUniversidade da Coruña · ESSwedish University of Agricultural Sciences · SEUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carboxylic acids have become interesting platform molecules in the last years due to their versatility to act as carbon sources for different microorganisms or as precursors for the chemical industry. Among carboxylic acids, short-chain fatty acids (SCFAs) such as acetic, propionic, butyric, valeric, and caproic acids can be biotechnologically produced in an anaerobic fermentation process from lignocellulose or other organic wastes of agricultural, industrial, or municipal origin. The biosynthesis of SCFAs is advantageous compared to chemical synthesis, since the latter relies on fossil-derived raw materials, expensive and toxic catalysts and harsh process conditions. This review article gives an overview on biosynthesis of SCFAs from complex waste products. Different applications of SCFAs are explored and how these acids can be considered as a source of bioproducts, aiming at the development of a circular economy. The use of SCFAs as platform molecules requires adequate concentration and separation processes that are also addressed in this review. Various microorganisms such as bacteria or oleaginous yeasts can efficiently use SCFA mixtures derived from anaerobic fermentation, an attribute that can be exploited in microbial electrolytic cells or to produce biopolymers such as microbial oils or polyhydroxyalkanoates. Promising technologies for the microbial conversion of SCFAs into bioproducts are outlined with recent examples, highlighting SCFAs as interesting platform molecules for the development of future bioeconomy.

Indexed as

Anaerobic fermentationBioproductsBiosynthesisCarboxylic acidsMicrobial electrolytic cellsMicrobial oilsOrganic waste streamsPlatform chemicalsPolyhydroxyalkanoatesShort-chain fatty acids

Identifiers

PMID37270640
PMCPMC10239154
OpenAlexW4379207548

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.