ArticleAnnals of clinical microbiology and antimicrobials2023
Bacterial peritonitis in paediatric appendicitis; microbial epidemiology and antimicrobial management.
Article in Annals of clinical microbiology and antimicrobials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 11 citations in OpenAlex.
- Laparoscopic Methylene Blue Photodynamic Therapy for Intraabdominal Infection: A Preclinical Feasibility Study in a Rabbit Model of Perforated Appendicitis.Lasers in surgery and medicine · 2026Article
- Impact of peritoneal fluid culture findings on postoperative outcomes in pediatric patients with complicated appendicitis.Pediatric surgery international · 2026Article
- Linking Antimicrobial Agent Resistance Profiles to Clinical Outcomes in Pediatric Perforated Appendicitis.Surgical infections · 2026Article
- Bacterial Etiology and Antimicrobial Susceptibility Patterns in Pediatric Intra-Abdominal Infections-Implications for Empirical Treatment and Antimicrobial Stewardship.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Bacterial pathogens and antimicrobial susceptibility profiles in acute appendicitis in children: a retrospective study at a tertiary hospital in Ningbo, China.Frontiers in pediatrics · 2026Article
- Microbiological spectrum and antimicrobial resistance patterns in pediatric acute appendicitis: implications for evidence-based empirical therapy.Frontiers in pediatrics · 2026Article
- Impact of peritoneal lavage on intra-abdominal abscess after laparoscopic appendectomy for perforated appendicitis: a propensity score matching analysis.BMC gastroenterology · 2025Article
- Review
- Better care for children with appendicitis: implementation of antibiotic stewardship optimizes postoperative therapy.GMS hygiene and infection control · 2025Article
- Intravenous meropenem and intraperitoneal use of 10% aqueous extract of Schinus terebinthifolius Raddi (Anacardiaceae) in elderly rats after induction of autogenous fecal peritonitis.Acta cirurgica brasileira · 2025Article
- Type and antibiotic susceptibility of bacteria cultured in paediatric acute appendicitis.Southern African journal of infectious diseases · 2025Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAppendicitis remains a common surgical emergency in children. Empirical antibacterial treatment is indicated to reduce infective complications. We investigate the bacterial pathogens identified intra-operatively during appendectomies in children to guide empirical surgical antimicrobial prophylaxis options.
methodsA retrospective analysis of patients (< 18 years old) undergoing an appendectomy across a multisite London hospital (Nov 2019-March 2022) was undertaken. Patient-related outcomes including length of hospital stay (LOS), days of antibacterial therapy (DOT), intra-operative microbiology and post-operative radiology reports were interrogated.
results304 patients underwent an appendectomy during this period; 39.1% of patients had intraoperative samples cultured. Bacterial pathogens were found in 73/119 (61.3%) cases; the most common isolates being Escherichia coli (42.0%), Pseudomonas aeruginosa (21.0%), milleri Streptococcus spp. (14.3%) and Bacteroides fragilis (5.9%). Polymicrobial infection was common (32/73). Isolation of Pseudomonas spp. from intra-operative sampling was associated with a greater LOS (7.0 vs. 5.0 days; p = 0.011) but nil effect on the incidence of postoperative collections. Presence of milleri Streptococcus spp. was associated with longer LOS (7.0 vs. 5.0 day; p = 0.007), DOT (12.0 vs. 8.5 day; p = 0.007) but had no observed outcome on postoperative collections (29.4% vs. 18.6%; p = 0.330). 48% of E. coli positive cultures were co-amoxiclav resistant and prolonged LOS compared to the non-resistant group (7.0 vs. 5.0 days; p = 0.040) but had no difference in post-operative collections (29.2% vs. 17.9%; p = 0.260).
conclusionA high proportion of children with appendicitis have Pseudomonas spp. isolated, leading to a prolonged LOS. Evolving Enterobacterales resistance and the presence of Pseudomonas spp. necessitate extended antibacterial coverage for paediatric appendectomies with evidence of peritonitis.
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