Evidence map›Paper›PMID 37270456›Full record

ArticleAnnals of biomedical engineering2023

Comparison of Methemoglobin, Deoxyhemoglobin, and Ferrous Nitrosyl Hemoglobin as Potential MRI Contrast Agents.

Roya Ayati, Kyle C Manwaring, Steven P Allen, Ronald W Day, Randy S Lewis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Roya AyatiDepartment of Chemical Engineering, Brigham Young University, 330 Engineering Building, Provo, UT, 84602, USA.
Kyle C ManwaringDepartment of Chemical Engineering, Brigham Young University, 330 Engineering Building, Provo, UT, 84602, USA.
Steven P AllenDepartment of Electrical and Computer Engineering, Brigham Young University, 450 Engineering Building, Provo, UT, 84602, USA.
Ronald W DayDepartment of Pediatrics, University of Utah and Primary Children's Hospital, Salt Lake City, UT, 84113, USA.
Randy S LewisDepartment of Chemical Engineering, Brigham Young University, 330 Engineering Building, Provo, UT, 84602, USA. randy.lewis@byu.edu.ORCID http://orcid.org/0000-0002-9673-322X
Brigham Young University · USPrimary Children's Hospital · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
NCATS NIH HHS UL1 TR002538NCATS NIH HHS UL1TR002538
6 · The paper itself

Abstract

Gadolinium-based contrast agents (GBCAs) are in widespread use to enhance magnetic resonance imaging for evaluating vascular pathology. However, safety concerns and limitations regarding the use of GBCAs has led to an increased interest in alternative contrast agents. Previously, methemoglobin (metHb) and oxygen-free hemoglobin (HHb) have been shown to increase the T1-weighted signal intensity of blood, which is associated with a decrease in the T1 parameter and an enhanced contrast of the image. Thus, a lower T1 value compared to the baseline value is favorable for imaging. However, it is unknown as to whether metHb or HHb would be a stronger and more appropriate contrast agent and to what extent the T1-weighted signal is affected by concentration. This study evaluated T1-weighted images of blood samples over a range of metHb and HHb concentrations, as well as ferrous nitrosyl hemoglobin (Hb

Indexed as

Contrast MediaMethemoglobinHemoglobinsMagnetic Resonance ImagingContrast MediadeoxyhemoglobinHemoglobinsMethemoglobinnitrosyl hemoglobinAngiographyBloodHemoglobinImaging

Identifiers

PMID37270456
PMCPMC10529426
OpenAlexW4379203227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.