ArticleGeroScience2024
DNA methylation clocks for clawed frogs reveal evolutionary conservation of epigenetic aging.
Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Genome-Wide DNA Methylation Patterns Predict Age in the Zebra Shark (Stegostoma tigrinum) and Provide Insight Into the Evolution of Vertebrate Aging.Molecular ecology · 2026Article
- Methods for analysing wildlife DNA methylation data.Conservation physiology · 2026Article
- A ternary-code DNA methylome atlas of mouse tissues.Genome biology · 2025Article
- State-of-the-Art Age Determination Methods for Amphibians and Reptiles.Animals : an open access journal from MDPI · 2025Review
- An epigenetic clock for Xenopus tropicalis.npj aging · 2025Article
- Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy.GeroScience · 2025Article
- Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?Frontiers in genetics · 2025Article
- Applicability of epigenetic age models to next-generation methylation arrays.Genome medicine · 2024Article
- Examining the Utility of the Mammalian Methylation Array for Pan-Mammalian Analysis of Monozygotic Twinning.Epigenomes · 2024Article
- Approaching the mystery of aging by the epigenetic clock.Primates; journal of primatology · 2024Article
- Article
- Somatic mutation as an explanation for epigenetic aging.bioRxiv : the preprint server for biology · 2023Article
- DNA methylation extends lifespan in the bumblebeeProceedings. Biological sciences · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
To address how conserved DNA methylation-based epigenetic aging is in diverse branches of the tree of life, we generated DNA methylation data from African clawed frogs (Xenopus laevis) and Western clawed frogs (Xenopus tropicalis) and built multiple epigenetic clocks. Dual species clocks were developed that apply to both humans and frogs (human-clawed frog clocks), supporting that epigenetic aging processes are evolutionary conserved outside mammals. Highly conserved positively age-related CpGs are located in neural-developmental genes such as uncx, tfap2d as well as nr4a2 implicated in age-associated disease. We conclude that signatures of epigenetic aging are evolutionary conserved between frogs and mammals and that the associated genes relate to neural processes, altogether opening opportunities to employ Xenopus as a model organism to study aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.