Evidence map›Paper›PMID 37270188›Full record

ArticleBMJ open2023

MODIFI: protocol for randomised feasibility study of eye-movement desensitisation and reprocessing therapy (EMDR) for functional neurological disorder (FND).

Sarah R Cope, Jared G Smith, Sharif El-Leithy, Serena Vanzan, Caitlin Pentland, Susannah Pick, Dawn Golder, Patricia Hogwood, Kati Turner, Jo Billings and 1 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05455450 (Randomised Feasibility Study of Eye Movement Desensitisation and Reprocessing Therapy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05455450 nacompletednot on this map

Randomised Feasibility Study of Eye Movement Desensitisation and Reprocessing Therapy (EMDR) for Functional Neurological Disorder (FND)

TypeinterventionalSponsorSouth West London and St George's Mental Health NHS TrustRan2022 to 2025Enrolled50ConditionsFunctional Neurological Symptom DisorderArmsEye movement desensitisation and reprocessing therapy, Neuropsychiatric care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Functional neurological disorder: Practical management.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sarah R CopeSouth West London and St George's Mental Health NHS Trust, Tooting, UK sarah.cope@swlstg.nhs.uk.ORCID 0000-0002-1672-9459
Jared G SmithPopulation Health Research Institute, St George's University of London, London, UK.
Sharif El-LeithyTraumatic Stress Service, South West London and St George's Mental Health NHS Trust, London, UK.
Serena VanzanClinical Research Unit, South West London and St George's Mental Health NHS Trust, London, UK.
Caitlin PentlandClinical Research Unit, South West London and St George's Mental Health NHS Trust, London, UK.
Susannah PickDepartment of Psychological Medicine, Institute of Psychiatry Psychology and Neuroscience, London, UK.ORCID 0000-0003-2001-6723
Dawn GolderFND Hope UK, London, UK.
Patricia HogwoodIndependent Researcher, London, UK.
Kati TurnerSouth West London and St George's Mental Health NHS Trust, Tooting, UK.
Jo BillingsDepartment of Psychiatry, University College London, London, UK.ORCID 0000-0003-1238-2440
Mark J EdwardsDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
South West London and St George's Mental Health NHS Trust · GBKing's College London · GBSt George's, University of London · GBUniversity College London · GB

Funding

Department of Health 202277Medical Research Council MR/V032771/1
6 · The paper itself

Abstract

introductionFunctional neurological disorder (FND) refers to an involuntary loss of control over and/or aberrant perception of the body. Common presenting symptoms are functional (non-epileptic) seizures, and functional motor disorder, for example, walking difficulties, weakness or tremor. Greater access to effective treatments would lead to reduced distress and disability; and reduce unnecessary healthcare costs.This study will examine eye-movement desensitisation and reprocessing therapy (EMDR) as a treatment for FND. EMDR is an evidence-based treatment for post-traumatic stress disorder (PTSD), but its use for other conditions is growing. An FND-specific EMDR protocol will be tested, and if the intervention proves feasible with promising clinical outcomes, progression to a substantive study could take place. METHODS AND ANALYSIS: Fifty adult patients diagnosed with FND will be recruited. It will be a single-blind randomised controlled trial with two arms: EMDR (plus standard neuropsychiatric care; NPC) and standard NPC. The two groups will be compared at baseline (T0), 3 months (T1), 6 months (T2) and 9 months (T3). Measures of feasibility include safety, recruitment, retention, treatment adherence and acceptability. Clinical outcome measures will assess health-related functioning/quality of life, ratings of FND symptoms and severity, depression, anxiety, PTSD, dissociation, service utilisation and other costs. Improvement and satisfaction ratings will also be assessed. Feasibility outcomes will be summarised using descriptive statistics. Exploratory analyses using (linear/logistic) mixed-effect models will examine the rate of change in the groups' clinical outcome measures across the four time-points.After the intervention period, a sample of participants, and clinicians, will be invited to attend semistructured interviews. The interviews will be analysed using reflexive thematic analysis. ETHICS AND DISSEMINATION: This study has been approved by the NHS West Midlands-Edgbaston Research Ethics Committee. Study findings will be published in open access peer-reviewed journals, presented at conferences, and communicated to participants and other relevant stakeholders.

trial registrationNCT05455450 (www. CLINICALTRIALS: gov).

Indexed as

Conversion DisorderEye Movement Desensitization ReprocessingStress Disorders, Post-TraumaticAdultFeasibility StudiesHumansQuality of LifeRandomized Controlled Trials as TopicSingle-Blind MethodTreatment Outcomeadult psychiatryclinical trialsneurology

Identifiers

PMID37270188
PMCPMC10255051
OpenAlexW4379259646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.