Evidence map›Paper›PMID 37270156›Full record

ArticleNeuropharmacology2023

Long-term α5 GABA A receptor negative allosteric modulator treatment reduces NMDAR-mediated neuronal excitation and maintains basal neuronal inhibition.

Jessica L Nuwer, Nadya Povysheva, Tija C Jacob

Open access · greenAbstract read
In one paragraph

Article in Neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jessica L NuwerDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nadya PovyshevaDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA.
Tija C JacobDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: tcj11@pitt.edu.
University of Pittsburgh · US

Funding

Training in the Neurobiology of Neurological DiseaseT32NS086749 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Omar El Gharbawie, REBECCA P SEAL · 2014 to 2026
$4.8M
Benzodiazepine treatment induced neuroplasticityR01MH114908 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACOB, TIJA C. · 2019 to 2022
$1.6M
NIMH NIH HHS R01 MH114908NINDS NIH HHS T32 NS086749
6 · The paper itself

Abstract

α5 subunit-containing GABA type-A receptors (α5 GABA

Indexed as

Receptors, GABA-AReceptors, N-Methyl-D-AspartateAnimalsCalciumgamma-Aminobutyric AcidGlutamatesHippocampusRatsSynapsesCalciumgamma-Aminobutyric AcidGlutamatesReceptors, GABA-AReceptors, N-Methyl-D-AspartateCalciumExcitatoryGABA(A) receptorGluN2AGluN2BInhibitoryNegative allosteric modulatorNMDA receptorPharmacologySynapseα5 subunit

Identifiers

PMID37270156
PMCPMC10527172
OpenAlexW4378977863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.