Evidence map›Paper›PMID 37269889›Full record

ArticleRespiratory physiology & neurobiology2023

Arginine vasopressin potentiates inspiratory bursting in hypoglossal motoneurons of neonatal mice.

K N Bolte, J C Wealing, A L Revill

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

K N BolteArizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, United States.
J C WealingArizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, United States.
A L RevillArizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, United States; Department of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ, United States. Electronic address: arevill@midwestern.edu.
Midwestern University · US

Funding

CHOLINERGIC MODULATION OF XII MOTONEURONS AND XII PREMOTONEURONSR15HL148870 · NHLBI · MIDWESTERN UNIVERSITY (GLENDALE AZ) · PI REVILL, ANN LOUISE · 2020 to 2020
$448k
NHLBI NIH HHS R15 HL148870
6 · The paper itself

Abstract

Vasopressin (AVP) acts as a neurotransmitter and its activity can potentiate respiratory activity. Hypoglossal (XII) motoneurons that innervate the tongue express V1a vasopressin receptors, which are excitatory. Therefore, we hypothesized that V1a receptor activation at XII motoneurons would potentiate inspiratory bursting. We developed this study to determine whether AVP can potentiate inspiratory bursting in rhythmic medullary slice preparations in neonatal (postnatal, P0-5) mice. Bath or local application of AVP potentiated inspiratory bursting compared to baseline XII inspiratory burst amplitude. Antagonizing V1a receptors revealed significant attenuation of the AVP-mediated potentiation of inspiratory bursting, while antagonism of oxytocin receptors (at which AVP has similar binding affinity) revealed a trend to attenuate AVP-mediated potentiation of inspiratory bursting. Finally, we discovered that the AVP-mediated potentiation of inspiratory bursting increases significantly with postnatal maturation from P0-5. Overall, these data support that AVP potentiates inspiratory bursting directly at XII motoneurons.

Indexed as

Arginine VasopressinHypoglossal NerveAnimalsAnimals, NewbornMiceMotor NeuronsVasopressinsArginine VasopressinVasopressinsAnti-diuretic hormoneBreathingHypoglossalInspiratory patternMotor neuronsNeuromodulationOxytocinRespirationV1a

Identifiers

PMID37269889
PMCPMC10443434
OpenAlexW4378974532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.