ArticleCell2023
Sleep is required to consolidate odor memory and remodel olfactory synapses.
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Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Effects of Sleep Deprivation and Neuromodulatory Interventions on Olfactory-Related Brain Function.Brain topography · 2026Trial
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- A circadian clock gene homolog regulates developmental timing and male mating circuitry iniScience · 2026Article
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- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ThebioRxiv : the preprint server for biology · 2025Article
- Non-visual light modulates behavioral memory and gene expression inbioRxiv : the preprint server for biology · 2025Article
- Association between weekend recovery sleep and risk of incident dementia: a prospective cohort study in the UK Biobank.Journal of neurology · 2025Article
- Review
- Artificial intelligence based assessment of clinical reasoning documentation: an observational study of the impact of the clinical learning environment on resident documentation quality.BMC medical education · 2025Observational
- Navigation strategies in Caenorhabditis elegans are differentially altered by learning.PLoS biology · 2025Article
- Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning.Nature communications · 2025Article
- Review
- Mechanism of the anterior cingulate cortex in sleep regulation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- β-chitosan attenuates hepatic macrophage-driven inflammation and reverses aging-related cognitive impairment.iScience · 2024Article
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Authors and funding
45 authors at 3 institutions in 1 country.
Rashmi ChandraDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Fatima FarahDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Fernando Muñoz-LobatoDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Anirudh BokkaDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Kelli L BenedettiDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Chantal BrueggemannDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Mashel Fatema A SaifuddinDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Julia M MillerDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Joy LiDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Eric ChangDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Aruna VarshneyDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Vanessa JimenezDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Anjana BaradwajDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Cibelle NassifDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Sara AlladinDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Kristine AndersenDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Angel J GarciaDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Veronica BiDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Sarah K NordquistDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Raymond L DunnDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Vanessa GarciaDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Kateryna TokalenkoDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Emily SoohooDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Fabiola BrisenoDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Sukhdeep KaurDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Malcolm HarrisDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Hazel GuillenDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Decklin ByrdDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Brandon FungDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Andrew E BykovDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Emma OdishoDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Bryan TsujimotoDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Alan TranDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Alex DuongDepartment of Biological Sciences, San José State University, San José, CA 95192, USA.
Kevin C DaigleDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rebekka PaisnerDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Carlos E ZuazoDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Christine LinDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Aarati AsundiDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Matthew A ChurginDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Christopher Fang-YenDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Martina BremerDepartment of Mathematics and Statistics, San José State University, San José, CA 95192, USA.
Saul KatoDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Miri K VanHovenDepartment of Biological Sciences, San José State University, San José, CA 95192, USA. Electronic address: miri.vanhoven@sjsu.edu.
Noëlle D L'ÉtoileDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: noelle.letoile@ucsf.edu.
San Jose State University · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US
Funding
WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9MCenter for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MOlfactory memory acquisition consolidation and recallR01DC005991 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI L 'ETOILE, NOELLE D · 2005 to 2022
$7.1MThe Effects of Stimulation and Sleep on Neural Circuit ConnectionsR01NS087544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Noelle D L 'Etoile, Miri Kerensa VanHoven · 2014 to 2026
$6.2MEmergence of Functional Network Dynamics from Single Cell PropertiesR35GM124735 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KATO, SAUL S · 2017 to 2021
$1.9MControlling neural circuits with single-cell resolution in behaving animalsR01NS084835 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI FANG-YEN, CHRISTOPHER · 2013 to 2017
$1.7MWide-field super-resolution spinning disk confocal microscopeS10OD028611 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2020 to 2020
$600kSpinning disk confocal / FRAP microscope for quantitative live cell imagingS10RR026758 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2010 to 2010
$500kMolecular Mechanisms that Regulate Neural Circuit FormationR15NS109803 · NINDS · SAN JOSE STATE UNIVERSITY · PI VANHOVEN, MIRI KERENSA · 2019 to 2019
$439kExploring the Role of OSM-9 in Odor Aversive Learning and Long-term MemoryF31DC019872 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAIFUDDIN, MASHEL FATEMA · 2021 to 2023
$127kClosed-loop control of neural dynamics and action selection in C elegansF31NS115572 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNN, RAYMOND LAKE · 2019 to 2021
$124kNCRR NIH HHS S10 RR026758NHGRI NIH HHS U24 HG002223NIDCD NIH HHS F31 DC014921NIDCD NIH HHS F31 DC019872NIDCD NIH HHS R01 DC005991NIGMS NIH HHS R35 GM124735NIH HHS P40 OD010440NIH HHS R24 OD010943NIH HHS S10 OD028611NINDS NIH HHS F31 NS115572NINDS NIH HHS R01 NS084835NINDS NIH HHS R01 NS087544NINDS NIH HHS R15 NS109803
Abstract
Animals with complex nervous systems demand sleep for memory consolidation and synaptic remodeling. Here, we show that, although the Caenorhabditis elegans nervous system has a limited number of neurons, sleep is necessary for both processes. In addition, it is unclear if, in any system, sleep collaborates with experience to alter synapses between specific neurons and whether this ultimately affects behavior. C. elegans neurons have defined connections and well-described contributions to behavior. We show that spaced odor-training and post-training sleep induce long-term memory. Memory consolidation, but not acquisition, requires a pair of interneurons, the AIYs, which play a role in odor-seeking behavior. In worms that consolidate memory, both sleep and odor conditioning are required to diminish inhibitory synaptic connections between the AWC chemosensory neurons and the AIYs. Thus, we demonstrate in a living organism that sleep is required for events immediately after training that drive memory consolidation and alter synaptic structures.
Indexed as
Caenorhabditis elegansOdorantsAnimalsSleepSmellSynapsesbehaviorC. eleganscircuitmemorymemory consolidationplasticitysingle cellsleepsynapsesystems consolidation
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