Evidence map›Paper›PMID 37269474›Full record

ReviewCurrent cardiology reports2023

The Role of MicroRNA in the Myocarditis: a Small Actor for a Great Role.

Cristina Chimenti, Michele Magnocavallo, Giampaolo Vetta, Maria Alfarano, Giulia Manguso, Francesco Ajmone, Federico Ballatore, Jacopo Costantino, Piera Ciaramella, Paolo Severino and 3 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current cardiology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Cristina ChimentiClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy. cristina.chimenti@uniroma1.it.ORCID 0000-0001-5954-3796
Michele MagnocavalloCardiology Division, Arrhythmology Unit, S. Giovanni Calibita Hospital, Isola Tiberina, Rome, Italy.
Giampaolo VettaDepartment of Clinical and Experimental Medicine, Cardiology Unit, University of Messina, Mesina, Italy.
Maria AlfaranoClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Giulia MangusoClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Francesco AjmoneClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Federico BallatoreClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Jacopo CostantinoClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Piera CiaramellaClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Paolo SeverinoClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Fabio MiraldiClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Carlo LavalleClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Carmine Dario VizzaClinical, Anestesiologic and Cardiovascular Sciences, La Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITFatebenefratelli Hospital · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewMyocarditis is an inflammation of the myocardium secondary to a variety of agents such as infectious pathogens, toxins, drugs, and autoimmune disorders. In our review, we provide an overview of miRNA biogenesis and their role in the etiology and pathogenesis of myocarditis, evaluating future directions for myocarditis management. RECENT

findingsAdvances in genetic manipulation techniques allowed to demonstrate the important role of RNA fragments, especially microRNAs (miRNAs), in cardiovascular pathogenesis. miRNAs are small non-coding RNA molecules that regulate the post-transcriptional gene expression. Advances in molecular techniques allowed to identify miRNA's role in pathogenesis of myocarditis. miRNAs are related to viral infection, inflammation, fibrosis, and apoptosis of cardiomyocytes, making them not only promising diagnostic markers but also prognostics and therapeutic targets in myocarditis. Of course, further real-world studies will be needed to assess the diagnostic accuracy and applicability of miRNA in the myocarditis diagnosis.

Indexed as

MicroRNAsMyocarditisHumansInflammationMyocardiumMyocytes, CardiacMicroRNAsDiagnosisExperimental myocarditisMicroRNAMyocarditisPathogenesis

Identifiers

PMID37269474
PMCPMC10307691
OpenAlexW4379260727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.