Evidence map›Paper›PMID 37269465›Full record

ArticleAging clinical and experimental research2023

Association of age-related eye diseases with cognitive frailty in older adults: a population-based study.

Mohammad Javad Ghanbarnia, Seyed Reza Hosseini, Mehrnoosh Ghasemi, Gholam Abbas Roustaei, Ebrahim Mekaniki, Reza Ghadimi, Ali Bijani, Seyed Ahmad Rasoulinejad

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In one paragraph

Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mohammad Javad GhanbarniaSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Seyed Reza HosseiniSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Mehrnoosh GhasemiDepartment of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Gholam Abbas RoustaeiDepartment of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Ebrahim MekanikiDepartment of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Reza GhadimiSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Ali BijaniSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Seyed Ahmad RasoulinejadDepartment of Ophthalmology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran. rasolisa2@gmail.com.ORCID http://orcid.org/0000-0002-7455-3754
Babol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related eye diseases and cognitive frailty (CF) are both important predictors of adverse health outcomes in older adults, however, little is known about their association.

aimsTo demonstrate the association between age-related eye diseases and cognitive frailty in a population of Iranian older adults.

methodsIn this cross-sectional, population-based study, we included 1136 individuals (female n = 514) aged 60 years and older (mean 68.8 ± 6.7 years) who participated in the second cycle of the Amirkola Health and Aging Project (AHAP) between 2016 and 2017. Cognitive function and frailty were evaluated based on Mini-Mental State Examination (MMSE) and the FRAIL scale respectively. Cognitive frailty was defined as coexistence of cognitive impairment (CI) and physical frailty (PF), excluding confirmed cases of dementia such as Alzheimer's disease. Cataract, diabetic retinopathy (DR), age-related macular degeneration (AMD), elevated intraocular pressure (IOP ≥ 21 mmHg) and glaucoma suspects (vertical cup to disc ratio (VCDR) ≥ 0.6) were diagnosed based on standardized grading protocols. Associations between eye diseases and cognitive frailty were evaluated through binary logistic regression analysis.

resultsOverall, CI, PF and CF were observed in 257 (22.6%), 319 (28.1%) and 114 (10.0%) participants respectively. After adjusting for confounders and ophthalmic conditions, individuals with cataract were more likely to have CF (OR 1.66; p-value 0.043), while DR, AMD, elevated IOP and glaucoma suspects (OR 1.32, 1.62, 1.42, 1.36, respectively) were not significantly associated with CF. Furthermore, cataract was significantly associated with CI (OR 1.50; p-value 0.022), but not with frailty (OR 1.18; p-value 0.313).

conclusionOlder adults with cataract were more likely to have cognitive frailty and cognitive impairment. This association demonstrates the implications of age-related eye diseases beyond ophthalmology and substantiates the need for further research involving cognitive frailty in the context of eye diseases and visual impairment.

Indexed as

CataractCognitive DysfunctionFrailtyGlaucomaAgedCognitionCross-Sectional StudiesFemaleFrail ElderlyHumansIranMaleMiddle AgedAge-related macular degenerationCataractCognitive impairmentDiabetic retinopathyFrailtyGlaucoma

Identifiers

PMID37269465
OpenAlexW4379207239

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.