ArticleJACC. Cardiovascular imaging2023
Stress-Related Neural Activity Associates With Coronary Plaque Vulnerability and Subsequent Cardiovascular Events.
Article in JACC. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The relation between stress-related neural activity assessed by brainEuropean journal of nuclear medicine and molecular imaging · 2025Pooled it
- Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress.Brain and behavior · 2026Article
- Biomolecular Pathways Linking Preoperative Chronic Stress to Postoperative Cardiovascular Dysfunction in Noncardiac Surgery.Biomolecules · 2026Review
- Amygdalar metabolic activity associated with cerebrovascular events and carotid-vertebral artery stenosis in takayasu arteritis.European journal of nuclear medicine and molecular imaging · 2026Article
- Allostatic load associated with all-cause and cause-specific mortality: a large prospective cohort study.BMC public health · 2026Article
- Physician burnout and type D personality relate to pericoronary fat phenotype and role of sympathetic activation: a cross-sectional study.Scientific reports · 2026Article
- Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Role of Exercise in Modulating the Brain-Heart Axis in Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Amygdala volume is not associated with MRI-based markers of early cardiovascular disease.Insights into imaging · 2026Article
- Bidirectional brain-heart communication in coronary heart disease: from coronary plaques to central autonomic networks.Frontiers in neuroscience · 2026Review
- Stress and Acute Coronary Syndrome.Cardiology research · 2025Review
- Association between inflammatory biomarkers, chronic stress, and pericoronary adipose tissue attenuation obtained with coronary CT.European heart journal. Cardiovascular Imaging · 2025Article
- Relation between resting amygdala activity and cardiovascular events in patients with cardiac sarcoidosis.European journal of nuclear medicine and molecular imaging · 2025Article
- The Heart-Brain Axis in the Artificial Intelligence Era: Integrating Old and New Insights Towards New Targeting and Innovative Neuro- and Cardio-Therapeutics.International journal of molecular sciences · 2025Review
- Advanced Detection and Therapeutic Monitoring of Atherosclerotic Plaque Using CD36-Targeted Lipid Core Probe.Pharmaceutics · 2025Article
- Correlation between hemodynamics assessed by FAI combined with CT-FFR and plaque characteristics in coronary artery stenosis.BMC medical imaging · 2025Article
- Neurobiological Mechanisms Link Bipolar Disorder to Cardiovascular Disease: A Retrospective Biobank Study of Adverse Event Risk and Contributory Mechanisms.Bipolar disorders · 2025Observational
- Article
- Association of resting amygdalar activity with persistent atrial fibrillation mediated by right atrial inflammation activity onQuantitative imaging in medicine and surgery · 2024Article
- Neurocardiac Axis Physiology and Clinical Applications.International journal of cardiology. Heart & vasculature · 2024Review
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Authors and funding
20 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStress-related neural activity (SNA) assessed by amygdalar activity can predict cardiovascular events. However, its mechanistic linkage with plaque vulnerability is not fully elucidated.
objectivesThe authors aimed to investigate the association of SNA with coronary plaque morphologic and inflammatory features as well as their ability in predicting major adverse cardiovascular events (MACE).
methodsA total of 299 patients with coronary artery disease (CAD) and without cancer underwent
resultsSNA was significant correlated with BMA (r = 0.39; P < 0.001) and FAI (r = 0.49; P < 0.001). Patients with heightened SNA are more likely to have HRP (40.7% vs 23.5%; P = 0.002) and increase risk of MACE (17.2% vs 5.1%, adjusted HR 3.22; 95% CI: 1.31-7.93; P = 0.011). Mediation analysis suggested that higher SNA associates with MACE via a serial mechanism involving BMA, FAI, and HRP.
conclusionsSNA is significantly correlated with FAI and HRP in patients with CAD. Furthermore, such neural activity was associated with MACE, which was mediated in part by leukopoietic activity in the bone marrow, coronary inflammation, and plaque vulnerability.
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