Evidence map›Paper›PMID 37269105›Full record

ArticleNeurorehabilitation and neural repair2023

Association of Dual-Task Gait Cost and White Matter Hyperintensity Burden Poststroke: Results From the ONDRI.

Frederico Pieruccini-Faria, Benjamin Cornish, Malcolm Binns, Julia Fraser, Seyyed M H Haddad, Kelly Sunderland, Joel Ramirez, Derek Beaton, Donna Kwan, Allison A Dilliott and 32 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. APOE4 carriers display loss of anticipatory cerebrovascular regulation across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
  5. Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 11 institutions in 1 country.

Frederico Pieruccini-FariaGait and Brain Lab, St. Joseph's Hospital, Parkwood Institute, Lawson Health Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.ORCID 0000-0002-7659-4285
Benjamin CornishNeuroscience, Mobility and Balance Lab (NiMBaL), Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Malcolm BinnsRotman Research Institute, Baycrest Centre, Toronto, ON, Cananda; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Julia FraserNeuroscience, Mobility and Balance Lab (NiMBaL), Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Seyyed M H HaddadDepartment of Medicine, Robarts Research Institute, Schulich of Medicine and Dentistry, Western University, London, Ontario, Canada.
Kelly SunderlandRotman Research Institute, Baycrest Centre, Toronto, ON, Cananda; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Joel RamirezHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Derek BeatonData Science & Advanced Analytics, St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.
Donna KwanCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Allison A DilliottDepartment of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Robarts Research Institute, Western University, London, ON, Canada.
Christopher ScottHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Yanina Sarquis-AdamsonGait and Brain Lab, St. Joseph's Hospital, Parkwood Institute, Lawson Health Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Alanna BlackGait and Brain Lab, St. Joseph's Hospital, Parkwood Institute, Lawson Health Research Institute, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Karen Van OoteghemNeuroscience, Mobility and Balance Lab (NiMBaL), Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Leanne CasaubonDepartment of Medicine, Sunnybrook HSC, University of Toronto; Dr. Sandra Black Centre for Brain Resilience and Recovery; Hurvitz Brain Sciences Research Program Director, Sunnybrook Research Institute; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Dar DowlatshahiDepartment of Medicine, University of Ottawa Brain and Mind Research Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ayman HassanThunder Bay Regional Research Institute, Northern Ontario School of Medicine, Thunder Bay, ON, Canada.
Jennifer MandziaDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Center, London, ON, Canada.
Demetrios SahlasDivision of Neurology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Gustavo SaposnikSt. Michaels Hospital, University of Toronto, Toronto, ON, Canada.
Brian TanRotman Research Institute, Baycrest Centre, Toronto, ON, Cananda; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Robert HegeleDepartment of Medicine, Robarts Research Institute, Schulich of Medicine and Dentistry, Western University, London, Ontario, Canada.
Dennis BulmanDepartment of Medicine, University of Ottawa Brain and Mind Research Institute and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Mahdi GhaniTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
John RobinsonDepartment of Medicine, Robarts Research Institute, Schulich of Medicine and Dentistry, Western University, London, Ontario, Canada.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Sali FarhanDepartment of Neurology and Neurosurgery, Department of Human Genetics, The Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Sean SymonsHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Nuwan NanayakkaraDepartment of Medicine, Robarts Research Institute, Schulich of Medicine and Dentistry, Western University, London, Ontario, Canada.
Stephen R ArnottRotman Research Institute, Baycrest Centre, Toronto, ON, Cananda; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Courtney BerezukHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Melissa HolmesHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Sabrina AdamoHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Miracle OzzoudeHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Mojdeh ZamyadiRotman Research Institute, Baycrest Centre, Toronto, ON, Cananda; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Wendy LouDalla Lana School of Public Health; University of Toronto, Toronto, ON, Canada.
Sujeevini SujanthanDepartment of Ophthalmology and Visual Sciences, Research Institute of the McGill University Health Center, Montreal, QC, Canada.
Robert BarthaDepartment of Medicine, Robarts Research Institute, Schulich of Medicine and Dentistry, Western University, London, Ontario, Canada.
Sandra E BlackDepartment of Medicine, Sunnybrook HSC, University of Toronto; Dr. Sandra Black Centre for Brain Resilience and Recovery; Hurvitz Brain Sciences Research Program Director, Sunnybrook Research Institute; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery Sunnybrook Health Sciences Centre, Toronto, ON, Canada.ORCID 0000-0001-7093-8289
Richard H SwartzHurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
William McIlroyNeuroscience, Mobility and Balance Lab (NiMBaL), Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Manuel Montero-OdassoDepartment of Medicine (Geriatrics) and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Western University · CASunnybrook Health Science Centre · CAUniversity of Toronto · CAUniversity of Waterloo · CASt. Michael's Hospital · CAUniversity of Ottawa · CAMcGill University Health Centre · CAMcMaster University · CAMontreal Neurological Institute and Hospital · CAQueen's University · CAThunder Bay Regional Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute change in gait speed while performing a mental task [dual-task gait cost (DTC)], and hyperintensity magnetic resonance imaging signals in white matter are both important disability predictors in older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC is associated with overall hyperintensity volume from specific major brain regions in poststroke.

methodsThis is a cohort study with a total of 123 older (69 ± 7 years of age) participants with history of stroke were included from the Ontario Neurodegenerative Disease Research Initiative. Participants were clinically assessed and had gait performance assessed under single- and dual-task conditions. Structural neuroimaging data were analyzed to measure both, white matter hyperintensity (WMH) and normal appearing volumes. Percentage of WMH volume in frontal, parietal, occipital, and temporal lobes as well as subcortical hyperintensities in basal ganglia + thalamus were the main outcomes. Multivariate models investigated associations between DTC and hyperintensity volumes, adjusted for age, sex, years of education, global cognition, vascular risk factors, APOE4 genotype, residual sensorimotor symptoms from previous stroke and brain volume.

resultsThere was a significant positive global linear association between DTC and hyperintensity burden (adjusted Wilks' λ = .87,

conclusionsIn poststroke, increased DTC may be an indicator of larger white matter damages, specifically in subcortical regions, which can potentially affect the overall cognitive processing and decrease gait automaticity by increasing the cortical control over patients' locomotion.

Indexed as

Neurodegenerative DiseasesStrokeWhite MatterAgedBrainCohort StudiesGaitHumansMagnetic Resonance Imagingatrophybrain structuredual-taskgaitstrokewhite matter hyperintensities

Identifiers

PMID37269105
PMCPMC10350733
OpenAlexW4379197089

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.