ArticleCNS neuroscience & therapeutics2023
A preliminary transcriptomic analysis of the orbitofrontal cortex of antisocial individuals.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal DMolecular psychiatry · 2025Article
- Differential Abnormality in Regional Brain Spontaneous Activity and Functional Connectivity in Patients of Non-Acute Subcortical Stroke With Versus Without Global Cognitive Functional Impairment.Brain and behavior · 2025Article
- "Amity Seizures": A previously unreported semiology localizing to a circuit between the right hippocampus and orbitofrontal area.Epilepsy & behavior reports · 2024Article
- A preliminary transcriptomic analysis of the orbitofrontal cortex of antisocial individuals.CNS neuroscience & therapeutics · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsAntisocial personality disorder (ASPD) and conduct disorder (CD) are characterized by a persistent pattern of violations of societal norms and others' rights. Ample evidence shows that the pathophysiology of these disorders is contributed by orbitofrontal cortex (OFC) alterations, yet the underlying molecular mechanisms remain elusive. To address this knowledge gap, we performed the first-ever RNA sequencing study of postmortem OFC samples from subjects with a lifetime diagnosis of ASPD and/or CD.
methodsThe transcriptomic profiles of OFC samples from subjects with ASPD and/or CD were compared to those of unaffected age-matched controls (n = 9/group).
resultsThe OFC of ASPD/CD-affected subjects displayed significant differences in the expression of 328 genes. Further gene-ontology analyses revealed an extensive downregulation of excitatory neuron transcripts and upregulation of astrocyte transcripts. These alterations were paralleled by significant modifications in synaptic regulation and glutamatergic neurotransmission pathways.
conclusionThese preliminary findings suggest that ASPD and CD feature a complex array of functional deficits in the pyramidal neurons and astrocytes of the OFC. In turn, these aberrances may contribute to the reduced OFC connectivity observed in antisocial subjects. Future analyses on larger cohorts are needed to validate these results.
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