ArticleRespiratory research2023
Machine diagnosis of chronic obstructive pulmonary disease using a novel fast-response capnometer.
Article in Respiratory research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Exploratory, Observational Clinical Evaluation of TidalSense's N-Tidal C Data-collector Capnometer to Collect Breathing Records in Patients With COPD
An Observational Proof-of-concept Study to Explore the Waveform Characteristics of Tidal Breathing Carbon Dioxide (CO2), Measured Using the N-Tidal C™ Device, in Different Breathing Conditions.
Characterisation of COPD Breathing Records During Exacerbations
A Longitudinal, Observational Study to Explore the Tidal Breathing Carbon Dioxide (TBCO2) Waveform, Measured Using the N-Tidal C Device, in Asthma
Who cites it
5 citing papers in PubMed.
- Quantification of smoking-related airway remodelling in COPD, using N-Tidal.Scientific reports · 2026Observational
- Breath-by-breath: unmasking cardio-respiratory conditions through capnography waveforms - the general breathing record study.European clinical respiratory journal · 2026Article
- Development and preliminary tests of a portable volumetric capnograph for outpatient use.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- A Novel Approach for the Detection and Severity Grading of Chronic Obstructive Pulmonary Disease Based on Transformed Volumetric Capnography.Bioengineering (Basel, Switzerland) · 2024Article
- [2027: A new year for a new epidemiological study of chronic obstructive pulmonary disease in Spain].Open respiratory archivesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundAlthough currently most widely used in mechanical ventilation and cardiopulmonary resuscitation, features of the carbon dioxide (CO
methodsCapnography data from four longitudinal observational studies (CBRS, GBRS, CBRS2 and ABRS) was analysed from 295 patients, generating a total of 88,186 capnograms. CO
resultsThe best machine learning model (XGBoost) performance provided a class-balanced AUROC of 0.985 ± 0.013, positive predictive value (PPV) of 0.914 ± 0.039 and sensitivity of 0.915 ± 0.066 for a diagnosis of COPD. The waveform features that are most important for driving classification are related to the alpha angle and expiratory plateau regions. These features correlated with spirometry readings, supporting their proposed properties as markers of COPD.
conclusionThe N-Tidal™ device can be used to accurately diagnose COPD in near-real-time, lending support to future use in a clinical setting.
trial registrationPlease see NCT03615365, NCT02814253, NCT04504838 and NCT03356288.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.