Evidence map›Paper›PMID 37268767›Full record

ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2023

Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities.

E Gkika, D Kostyszyn, T Fechter, C Moustakis, F Ernst, J Boda-Heggemann, G Sarria, K Dieckmann, S Dobiasch, M N Duma and 23 more

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In one paragraph

Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 4 countries.

E GkikaDepartment of Radiation Oncology, University Medical Center Freiburg, Robert Koch Str 3, Freiburg, Germany. eleni.gkika@uniklinik-freiburg.de.ORCID 0000-0001-5455-252X
D KostyszynDepartment of Radiation Oncology, University Medical Center Freiburg, Robert Koch Str 3, Freiburg, Germany.
T FechterDepartment of Radiation Oncology, University Medical Center Freiburg, Robert Koch Str 3, Freiburg, Germany.
C MoustakisDepartment of Radiation Oncology, University Medical Center Muenster, Muenster, Germany.
F ErnstInstitute for Robotics and Cognitive Systems, University of Luebeck, Luebeck, Germany.
J Boda-HeggemannDepartment of Radiation Oncology, Faculty of Medicine Mannheim, Department of Radiation Oncology, University of Heidelberg, Mannheim, Germany.
G SarriaDepartment of Radiation Oncology, University Hospital Bonn, Bonn, Germany.
K DieckmannDepartment of Radiation Oncology, University Departments of the MedUni Vienna, Vienna General Hospital, Vienna, Austria.
S DobiaschDepartment of Radiation Oncology, Klinikum Rechts der Isar, TU Munich, Munich, Germany.
M N DumaDepartment of Radiotherapy and Radiation Oncology, University Hospital Jena, Friedrich-Schiller University, Jena, Germany.
F EberleDepartment of Radiation Oncology, University Hospital Marburg, Marburg, Germany.
K KroegerDepartment of Radiation Oncology, University Medical Center Muenster, Muenster, Germany.
B HäusslerRadiation Oncology Dr. Häussler/Dr. Schorer, Munich, Germany.
V IzaguirreDepartment of Radiation Oncology, University Hospital Halle, Halle, Germany.
D JazmatiProton Therapy Centre, University Hospital Essen, Essen, Germany.
S LautenschlägerDepartment of Radiation Oncology, University Hospital, Marburg, Germany.
F LohausDepartment of Radiation Oncology, University Hospital Dresden, Dresden, Germany.
F MantelDepartment of Radiation Oncology, University Hospital Würzburg, Würzburg, Germany.
J MenzelDepartment of Radiation Oncology, University Hospital Hannover, Hannover, Germany.
S PachmannDepartment of Radiation Oncology, Weilheim Clinic, Weilheim, Germany.
M PavicDepartment of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
K RadlanskiDepartment of Radiation Oncology, Charite, University Hospital Berlin, Berlin, Germany.
O RiestererCentre for Radiation Oncology KSA-KSB, Kantonsspital Aarau, Aarau, Switzerland.
S GerumDepartment of Radiation Oncology, University Clinic, Paracelsus Medical University (PMU), Salzburg, Austria.
F RöderDepartment of Radiation Oncology, University Clinic, Paracelsus Medical University (PMU), Salzburg, Austria.
J WillnerDepartment of Radiation Oncology, University Hospital Bayreuth, Bayreuth, Germany.
S BarczykCenter for Radiation Oncology, Belegklinik am St. Agnes-Hospital, Bocholt, Germany.
D ImhoffDepartment of Radiation Oncology, Saphir Radiosurgery, University Hospital Frankfurt, Frankfurt, Germany.
O BlanckSaphir Radiosurgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
A WittigDepartment of Radiotherapy and Radiation Oncology, University Hospital Jena, Friedrich-Schiller University, Jena, Germany.
M GuckenbergerDepartment of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Anca-L GrosuDepartment of Radiation Oncology, University Medical Center Freiburg, Robert Koch Str 3, Freiburg, Germany.
T B BrunnerDepartment of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, Graz, Austria.
University Medical Center Freiburg · DEFriedrich Schiller University Jena · DEParacelsus Medical University · ATPhilipps University of Marburg · DEUniversity of Zurich · CHBayreuth Medical Center · DECharité - Universitätsmedizin Berlin · DEEssen University Hospital · DEGoethe University Frankfurt · DEKantonsspital Aarau · CHMedical University of Graz · ATSaint Agnes Hospital · USTUM Klinikum · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Bonn · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital in Halle · DEUniversity Hospital Schleswig-Holstein · DEUniversity of Lübeck · DEUniversity of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modalities on the definition of the target volumes.

methodsTwo cases of locally advanced PACA and one local recurrence were selected from a large SBRT database. Delineation was based on either a planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, and w/wo diagnostic MRI. Novel compared to other studies, a combination of four metrics was used to integrate several aspects of target volume segmentation: the Dice coefficient (DSC), the Hausdorff distance (HD), the probabilistic distance (PBD), and the volumetric similarity (VS).

resultsFor all three GTVs, the median DSC was 0.75 (range 0.17-0.95), the median HD 15 (range 3.22-67.11) mm, the median PBD 0.33 (range 0.06-4.86), and the median VS was 0.88 (range 0.31-1). For ITVs and PTVs the results were similar. When comparing the imaging modalities for delineation, the best agreement for the GTV was achieved using PET/CT, and for the ITV and PTV using 4D PET/CT, in treatment position with abdominal compression.

conclusionOverall, there was good GTV agreement (DSC). Combined metrics appeared to allow a more valid detection of interobserver variation. For SBRT, either 4D PET/CT or 3D PET/CT in treatment position with abdominal compression leads to better agreement and should be considered as a very useful imaging modality for the definition of treatment volumes in pancreatic SBRT. Contouring does not appear to be the weakest link in the treatment planning chain of SBRT for PACA.

Indexed as

AdenocarcinomaLung NeoplasmsPancreatic NeoplasmsRadiosurgeryHumansObserver VariationPositron Emission Tomography Computed TomographyRadiotherapy Planning, Computer-AssistedImagingInterobserver agreementPancreatic cancerStereotactic radiotherapyTarget volume definition

Identifiers

PMID37268767
PMCPMC10598103
OpenAlexW4379197710

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.