Evidence map›Paper›PMID 37268744›Full record

ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2023

Disruption of zinc (II) binding and dimeric protein structure of the XIAP-RING domain by copper (I) ions.

Kathryn E Splan, Sylvia R Choi, Ruth E Claycomb, Isaiah K Eckart-Frank, Shreya Nagdev, Madeline E Rodemeier

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Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kathryn E SplanDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA. splank@macalester.edu.
Sylvia R ChoiDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA.
Ruth E ClaycombDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA.
Isaiah K Eckart-FrankDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA.
Shreya NagdevDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA.
Madeline E RodemeierDepartment of Chemistry, Macalester College, 1600 Grand Avenue, Saint Paul, MN, 55105, USA.
Macalester College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulation of metalloprotein structure and function via metal ion substitution may constitute a molecular basis for metal ion toxicity and/or metal-mediated functional control. The X-linked Inhibitor of Apoptosis Protein (XIAP) is a metalloprotein that requires zinc for proper structure and function. In addition to its role as a modulator of apoptosis, XIAP has been implicated in copper homeostasis. Given the similar coordination preferences of copper and zinc, investigation of XIAP structure and function upon interaction with copper is relevant. The Really Interesting New Gene (RING) domain of XIAP is representative of a class of zinc finger proteins that utilize a bi-nuclear zinc-binding motif to maintain proper structure and ubiquitin ligase function. Herein, we report the characterization of copper (I) binding to the Zn

Indexed as

CopperMetalloproteinsProtein BindingRING Finger DomainsUbiquitinsX-Linked Inhibitor of Apoptosis ProteinZincCopperMetalloproteinsUbiquitinsX-Linked Inhibitor of Apoptosis ProteinZincCopperMetalloproteinRINGX-linked inhibitor of apoptosisZinc finger

Identifiers

PMID37268744
OpenAlexW4379117732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.