Evidence map›Paper›PMID 37268691›Full record

ArticleNPJ precision oncology2023

CT radiomic signature predicts survival and chemotherapy benefit in stage I and II HPV-associated oropharyngeal carcinoma.

Bolin Song, Kailin Yang, Vidya Sankar Viswanathan, Xiangxue Wang, Jonathan Lee, Sarah Stock, Pingfu Fu, Cheng Lu, Shlomo Koyfman, James S Lewis and 1 more

Open access · goldAbstract read
In one paragraph

Article in NPJ precision oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Observational
  3. Personalization of Radiotherapy Dose in HPV Positive Oropharynx Cancer Using GARD.medRxiv : the preprint server for health sciences · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Bolin SongCenter for Computational Imaging and Personalized Diagnostics, Emory University, Atlanta, GA, USA.
Kailin YangDepartment of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
Vidya Sankar ViswanathanCenter for Computational Imaging and Personalized Diagnostics, Emory University, Atlanta, GA, USA.
Xiangxue WangSchool of Automation, Nanjing University of Information Science and Technology, Nanjing, China.ORCID http://orcid.org/0000-0003-3341-9871
Jonathan LeeImaging Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-5955-5145
Sarah StockImaging Institute, Cleveland Clinic, Cleveland, OH, USA.
Pingfu FuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-2334-5218
Cheng LuCenter for Computational Imaging and Personalized Diagnostics, Emory University, Atlanta, GA, USA.
Shlomo KoyfmanDepartment of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
James S LewisDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Anant MadabhushiCenter for Computational Imaging and Personalized Diagnostics, Emory University, Atlanta, GA, USA. anantm@emory.edu.ORCID http://orcid.org/0000-0002-5741-0399
Cleveland Clinic · USEmory University · USCase Western Reserve University · USNanjing University of Information Science and Technology · CNVanderbilt University Medical Center · US

Funding

Oral Cavity Quantitative Histomorphometric Risk Classifier (OHbIC) in Oral Cavity Squamous Cell Carcinoma (OC-SCC)R01CA249992 · NCI · EMORY UNIVERSITY · PI LEWIS, JAMES, MADABHUSHI, ANANT · 2021 to 2025
$3.2M
Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Division of Cancer Prevention, National Cancer Institute (NCI Division of Cancer Prevention) R01CA202752-01A1Division of Cancer Prevention, National Cancer Institute (NCI Division of Cancer Prevention) R01CA208236-01A1Division of Cancer Prevention, National Cancer Institute (NCI Division of Cancer Prevention) R01CA249992-01A1
6 · The paper itself

Abstract

Chemoradiation is a common therapeutic regimen for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). However, not all patients benefit from chemotherapy, especially patients with low-risk characteristics. We aim to develop and validate a prognostic and predictive radiomic image signature (pRiS) to inform survival and chemotherapy benefit using computed tomography (CT) scans from 491 stage I and II HPV-associated OPSCC, which were divided into three cohorts D

Identifiers

PMID37268691
PMCPMC10238543
OpenAlexW4379185125

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.