ArticleNature communications2023
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
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Who cites it
35 citing papers in PubMed, 42 citations in OpenAlex.
- A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.Nature genetics · 2026Article
- Partitioned blood pressure polygenic risk reveals differential genetic effects of tissue-specific enhancers and their interactions on cardiovascular disease.Research square · 2026Article
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- Admixture-informed polygenic risk reporting using the ePRS framework.Nature communications · 2026Article
- Estimating population structure using epigenome-wide methylation data.Briefings in bioinformatics · 2026Article
- Polygenic Risk for Pre-Eclampsia and the Long-Term Risk of Incident Hypertension and Cardiovascular Disease: A Population-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Precision nutrition for hypertension: tea, coffee, antioxidant vitamins interactions with polygenic risk in multi-ethnic populations.European journal of clinical nutrition · 2026Article
- Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk.BMC medicine · 2026Article
- A deep ensemble encoder network method for improved polygenic risk score prediction.BioData mining · 2026Article
- Improving performance of polygenic risk scores for hypertension across two ancestry groups.PloS one · 2026Article
- Pathway-specific polygenic risk scores for blood pressure traits in a West African cohort.Frontiers in cardiovascular medicine · 2026Article
- Polygenic risk score translation across diverse populations.Frontiers in cardiovascular medicine · 2026Review
- Exploration of the causal relationship between inflammatory cytokines and type 2 diabetes via mendelian randomization and polygenic score.Frontiers in immunology · 2026Article
- Polygenic Risk Scores for Preeclampsia Prediction Beyond Gold-Standard Clinical Models in Multiethnic Populations.Journal of the American Heart Association · 2025Article
- Improving performance of polygenic risk scores for hypertension across two ancestry groups.medRxiv : the preprint server for health sciences · 2025Article
- A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations.medRxiv : the preprint server for health sciences · 2025Article
- Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus in Hispanic and Latino communities.Communications medicine · 2025Article
- Estimating population structure using epigenome-wide methylation data.medRxiv : the preprint server for health sciences · 2025Article
- Leveraging the All of Us research program to advance heart, lung, blood, and sleep research.American journal of epidemiology · 2025Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 2 countries.
Nuzulul Kurniansyah *Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Matthew O Goodman *Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Alyna T KhanDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Jiongming WangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Elena FeofanovaHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-1428-7199
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0003-2749-1279
Jennifer E HuffmanMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.ORCID 0000-0002-9672-2491
Tanika KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Tali ElfassyDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0002-7528-7988
Xiuqing GuoDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Walter PalmasDepartment of Medicine, Columbia University Medical Center, New York, NY, USA.
Henry J LinDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-6771-0486
Shih-Jen HwangThe Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD, USA.
Yan GaoThe Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Kendra YoungDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.ORCID 0000-0002-8664-7635
Gregory L KinneyDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.ORCID 0000-0002-5218-4986
Jennifer A SmithDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
Bing YuHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-4818-1077
Simin LiuCenter for Global Cardiometabolic Health, Department of Epidemiology, Brown University, Providence, RI, USA.ORCID 0000-0003-2098-3844
Sylvia Wassertheil-SmollerDepartment of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0002-5447-4653
JoAnn E MansonDepartment of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0003-0037-411X
Yii-Der Ida ChenDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0003-1741-3517
I-Te LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, 40705, Taiwan.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8527-8145
Donald M Lloyd-JonesDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Sebastian ZöllnerDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7362-156X
Myriam FornageHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0677-8158
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID 0000-0002-7986-8560
Adolfo CorreaDepartments of Medicine and Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.ORCID 0000-0002-9501-600X
Bruce M PsatyDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Donna K ArnettOffice of the Provost, University of South Carolina, Columbia, SC, USA.ORCID 0000-0003-2219-657X
Carmen R IsasiDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0003-2700-9593
Stephen S RichCenter for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Robert C KaplanDepartment of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-6585-1610
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Daniel LevyThe Population Sciences Branch of the National Heart, Lung and Blood Institute, Bethesda, MD, USA.
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6381-4296
Tamar SoferDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA. tsofer@bidmc.harvard.edu.ORCID 0000-0001-8520-8860
Brigham and Women's Hospital · USUCLA Medical Center · USUniversity of Washington · USAlbert Einstein College of Medicine · USThe University of Texas Health Science Center at Houston · USUniversity of Michigan · USColorado School of Public Health · USJackson Memorial Hospital · USNational Heart Lung and Blood Institute · USBrown Foundation · USBrown University · USCase Western Reserve University · USColumbia University Irving Medical Center · USFred Hutch Cancer Center · USNational Yang Ming Chiao Tung University · TWNorthwestern University · USTulane University · USUniversity of Maryland, Baltimore · USUniversity of Miami · USUniversity of North Carolina at Chapel Hill · US
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MNHLBI NIH HHS F32 HL152555NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL161012NHLBI NIH HHS R35 HL135818NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196
Abstract
We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare "clumping-and-thresholding" (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approaches that sum PRSs with and without weights, including PRS-CSx. We use datasets from the MGB Biobank, TOPMed study, UK biobank, and from All of Us to train, assess, and validate PRSs in groups defined by self-reported race/ethnic background (Asian, Black, Hispanic/Latino, and White). For both SBP and DBP, the PRS-CSx based PRS, constructed as a weighted sum of PRSs developed from multiple independent GWAS, perform best across all race/ethnic backgrounds. Stratified analysis in All of Us shows that PRSs are better predictive of BP in females compared to males, individuals without obesity, and middle-aged (40-60 years) compared to older and younger individuals.
Indexed as
Population HealthBlood PressureEthnicityFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMultifactorial InheritanceRisk Factors
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