Evidence map›Paper›PMID 37268433›Full record

ArticleNeurology2023

Association of Cortical Gyrification With Imaging and Serum Biomarkers in Patients With Parkinson Disease.

Yuanchao Zhang, Yu Zhang, Chengjie Mao, Zhen Jiang, Guohua Fan, Erlei Wang, Yifan Chen, Lena Palaniyappan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yuanchao ZhangFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada. erlei_wang_jyj@163.com yuanchao.zhang8@gmail.com.
Yu ZhangFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada. erlei_wang_jyj@163.com yuanchao.zhang8@gmail.com.ORCID 0000-0001-7159-4561
Chengjie MaoFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada.
Zhen JiangFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada.
Guohua FanFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada.
Erlei WangFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada. erlei_wang_jyj@163.com yuanchao.zhang8@gmail.com.
Yifan ChenFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada.
Lena PalaniyappanFrom the School of Life Science and Technology (Yuanchao Zhang, Y.C.), University of Electronic Science and Technology of China, Chengdu, Sichuan; Artificial Intelligence Research Institute (Yu Zhang), Zhejiang Lab, Hangzhou; Department of Neurology (C.M.), and Department of Radiology (Z.J., G.F., E.W.), The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; and Douglas Mental Health University Institute (L.P.), McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-1640-7182
University of Electronic Science and Technology of China · CNDouglas Mental Health University Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesPathologic progression across the cortex is a key feature of Parkinson disease (PD). Cortical gyrification is a morphologic feature of human cerebral cortex that is tightly linked to the integrity of underlying axonal connectivity. Monitoring cortical gyrification reductions may provide a sensitive marker of progression through structural connectivity, preceding the progressive stages of PD pathology. We aimed to examine the progressive cortical gyrification reductions and their associations with overlying cortical thickness, white matter (WM) integrity, striatum dopamine availability, serum neurofilament light (NfL) chain, and CSF α-synuclein levels in PD.

methodsThis study included a longitudinal dataset with baseline (T0), 1-year (T1), and 4-year (T4) follow-ups and 2 cross-sectional datasets. Local gyrification index (LGI) was computed from T1-weighted MRI data to measure cortical gyrification. Fractional anisotropy (FA) was computed from diffusion-weighted MRI data to measure WM integrity. Striatal binding ratio (SBR) was measured from

resultsThe longitudinal dataset included 113 patients with de novo PD and 55 healthy controls (HCs). The cross-sectional datasets included 116 patients with relatively more advanced PD and 85 HCs. Compared with HCs, patients with de novo PD showed accelerated LGI and FA reductions over 1-year period and a further decline at 4-year follow-up. Across the 3 time points, the LGI paralleled and correlated with FA ( DISCUSSION: We demonstrated progressive reductions in cortical gyrification that were robustly associated with WM microstructure, striatum dopamine availability, and serum NfL level in PD. Our findings may contribute biomarkers for PD progression and potential pathways for early interventions of PD.

Indexed as

alpha-SynucleinParkinson DiseaseBiomarkersCerebral CortexCross-Sectional StudiesDopamineHumansMagnetic Resonance Imagingalpha-SynucleinBiomarkersDopamine

Identifiers

PMID37268433
PMCPMC10382266
OpenAlexW4379114581

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.