Evidence map›Paper›PMID 37268423›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2023

MIRD Pamphlet No. 28, Part 2: Comparative Evaluation of MIRDcalc Dosimetry Software Across a Compendium of Diagnostic Radiopharmaceuticals.

Lukas M Carter, Juan C Ocampo Ramos, Edmond A Olguin, Justin L Brown, Daniel Lafontaine, Derek W Jokisch, Wesley E Bolch, Adam L Kesner

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. MIRD Pamphlet No. 30: MIRDfit-A Tool for Fitting of Biodistribution Time-Activity Data for Internal Dosimetry.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  8. First-in-human evaluation of 6-bromo-7-[European journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Single Chelator-Minibody Theranostic Agents forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Dosimetry of [EJNMMI radiopharmacy and chemistry · 2023
    Article
  11. Addendum to MIRD Pamphlet No. 28.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. MIRD Pamphlet No. 28, Part 1: MIRDcalc-A Software Tool for Medical Internal Radiation Dosimetry.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  13. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lukas M CarterDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York; carterl1@mskcc.org.
Juan C Ocampo RamosDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Edmond A OlguinBeth Israel Deaconess Medical Center, Department of Radiology, Harvard Medical School, Boston, Massachusetts.
Justin L BrownJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Daniel LafontaineDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Derek W JokischDepartment of Physics and Engineering, Francis Marion University, Florence, South Carolina; and.
Wesley E BolchJ. Crayton Pruitt Department of Biomedical Engineering, University of Florida, Gainesville, Florida.
Adam L KesnerDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USUniversity of Florida · USFrancis Marion University · USHarvard University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
MIRDCalc – A Community Tool for Deriving and Reporting Patient Organ Doses in Nuclear Medicine, Computed Tomography, and Hybrid ImagingU01EB028234 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI BOLCH, WESLEY E, KESNER, ADAM LEON · 2019 to 2023
$3.2M
Development of a Novel Peptide Platform for Targeted PET Imaging and Radiotherapy of Breast CancerF32EB025050 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI CARTER, LUKAS MICHAEL · 2017 to 2019
$179k
NCI NIH HHS P30 CA008748NIBIB NIH HHS F32 EB025050NIBIB NIH HHS U01 EB028234
6 · The paper itself

Abstract

Radiopharmaceutical dosimetry is usually estimated via organ-level MIRD schema-style formalisms, which form the computational basis for commonly used clinical and research dosimetry software. Recently, MIRDcalc internal dosimetry software was developed to provide a freely available organ-level dosimetry solution that incorporates up-to-date models of human anatomy, addresses uncertainty in radiopharmaceutical biokinetics and patient organ masses, and offers a 1-screen user interface as well as quality assurance tools. The present work describes the validation of MIRDcalc and, secondarily, provides a compendium of radiopharmaceutical dose coefficients obtained with MIRDcalc. Biokinetic data for about 70 currently and historically used radiopharmaceuticals were obtained from the International Commission on Radiological Protection (ICRP) publication 128 radiopharmaceutical data compendium. Absorbed dose and effective dose coefficients were derived from the biokinetic datasets using MIRDcalc, IDAC-Dose, and OLINDA software. The dose coefficients obtained with MIRDcalc were systematically compared against the other software-derived dose coefficients and those originally presented in ICRP publication 128. Dose coefficients computed with MIRDcalc and IDAC-Dose showed excellent overall agreement. The dose coefficients derived from other software and the dose coefficients promulgated in ICRP publication 128 both were in reasonable agreement with the dose coefficients computed with MIRDcalc. Future work should expand the scope of the validation to include personalized dosimetry calculations.

Indexed as

PamphletsRadiopharmaceuticalsHumansPhantoms, ImagingRadiation DosageRadiometrySoftwareRadiopharmaceuticalsdosimetryMIRDMIRDcalcradiopharmaceuticals

Identifiers

PMID37268423
PMCPMC10394313
OpenAlexW4379114024

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.