Evidence map›Paper›PMID 37268418›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Inference of Electrical Stimulation Sensitivity from Recorded Activity of Primate Retinal Ganglion Cells.

Sasidhar S Madugula, Ramandeep Vilkhu, Nishal P Shah, Lauren E Grosberg, Alexandra Kling, Alex R Gogliettino, Huy Nguyen, Paweł Hottowy, Alexander Sher, Alan M Litke and 1 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. High-Fidelity Reproduction of Visual Signals by Electrical Stimulation in the Central Primate Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Sasidhar S MadugulaNeurosciences PhD Program, Stanford University, Stanford, California 94305 sasidhar@stanford.edu.ORCID 0000-0002-4519-5249
Ramandeep VilkhuDepartment of Electrical Engineering, Stanford University, Stanford, California 94305.
Nishal P ShahDepartment of Neurosurgery, Stanford University, Stanford, California 94305.
Lauren E GrosbergDepartment of Neurosurgery, Stanford University, Stanford, California 94305.
Alexandra KlingDepartment of Neurosurgery, Stanford University, Stanford, California 94305.
Alex R GogliettinoNeurosciences PhD Program, Stanford University, Stanford, California 94305.
Huy NguyenDepartment of Neurosurgery, Stanford University, Stanford, California 94305.
Paweł HottowyFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland 30-059.
Alexander SherSanta Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064.
Alan M LitkeSanta Cruz Institute for Particle Physics, University of California, Santa Cruz, California 95064.ORCID 0000-0003-3973-3642
E J ChichilniskyDepartment of Neurosurgery, Stanford University, Stanford, California 94305.ORCID 0000-0002-5613-0248
Stanford University · USUniversity of California, Santa Cruz · USAGH University of Krakow · PLMeta (Israel) · ILNeurosciences Institute · US

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Core Grant for Vision ResearchP30EY019005 · NEI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ALBRIGHT, THOMAS D · 2009 to 2018
$7.7M
Unique physiological properties of novel ganglion cell types in primate retinaR01EY029247 · NEI · STANFORD UNIVERSITY · PI EDUARDO CHICHILNISKY, Michael B Manookin · 2018 to 2026
$4.7M
Patterned Electrical Stimulation of the Retina for High-Resolution ProsthesesR01EY021271 · NEI · STANFORD UNIVERSITY · PI EDUARDO CHICHILNISKY · 2011 to 2026
$4.6M
Bi-directional neural interface for probing parallel visual pathwaysR01EY032900 · NEI · STANFORD UNIVERSITY · PI CHICHILNISKY, EDUARDO, COGAN, STUART F · 2021 to 2024
$2.8M
Relating spontaneous activity to electrical stimulation properties of primate retinal ganglion cellsF30EY030776 · NEI · STANFORD UNIVERSITY · PI MADUGULA, SASIDHAR · 2019 to 2022
$158k
NEI NIH HHS F30 EY030776NEI NIH HHS P30 EY019005NEI NIH HHS R01 EY021271NEI NIH HHS R01 EY029247NEI NIH HHS R01 EY032900NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

High-fidelity electronic implants can in principle restore the function of neural circuits by precisely activating neurons via extracellular stimulation. However, direct characterization of the individual electrical sensitivity of a large population of target neurons, to precisely control their activity, can be difficult or impossible. A potential solution is to leverage biophysical principles to infer sensitivity to electrical stimulation from features of spontaneous electrical activity, which can be recorded relatively easily. Here, this approach is developed and its potential value for vision restoration is tested quantitatively using large-scale multielectrode stimulation and recording from retinal ganglion cells (RGCs) of male and female macaque monkeys

Indexed as

RetinaRetinal Ganglion CellsAction PotentialsAnimalsElectric StimulationFemaleHumansMalePrimatesbiophysicsmacular degenerationmultielectrode arrayprimateretinal electrophysiologyretinal ganglion cells

Identifiers

PMID37268418
PMCPMC10312054
OpenAlexW4379136440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.