ReviewNeuroscience and biobehavioral reviews2023
Insights from personalized models of brain and behavior for identifying biomarkers in psychiatry.
Review in Neuroscience and biobehavioral reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Development of functional topography of the default mode subnetworks revealed by precision mapping.Developmental cognitive neuroscience · 2026Article
- Advantages of combining multiple eye-tracking paradigms for distinguishing young autistic from non-autistic children.Molecular autism · 2026Article
- Dense longitudinal neuroimaging reveals individual brain change trajectories.Trends in cognitive sciences · 2026Review
- Nonergodicity and Simpson's paradox in neurocognitive dynamics of cognitive control.Nature communications · 2026Article
- Personalized brain decoding of spontaneous pain in individuals with chronic pain.Nature neuroscience · 2026Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.Human brain mapping · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Dense Phenotyping of Human Brain Network Organization Using Precision fMRI.Annual review of psychology · 2026Review
- Neurodatascience: Past, Present, and Future.Data science in science · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Special Issue "Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies".International journal of molecular sciences · 2025Article
- Precision Imaging for Intraindividual Investigation of the Reward Response.bioRxiv : the preprint server for biology · 2025Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- More than just a phase: adolescence as a window into how the brain generates behavior.Current directions in psychological science · 2025Article
- Sample size matters when estimating test-retest reliability of behaviour.Behavior research methods · 2025Article
- Optimizing working memory assessment: development of shortened versions of complex spans, updating, and binding tasks.Psychological research · 2025Article
- Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.Neurobiology of aging · 2025Review
- Trait state occasion (TSO) modeling of event-related potentials (ERPs).Biological psychology · 2025Article
- Group-to-individual generalizability and individual-level inferences in cognitive neuroscience.Neuroscience and biobehavioral reviews · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A main goal in translational neuroscience is to identify neural correlates of psychopathology ("biomarkers") that can be used to facilitate diagnosis, prognosis, and treatment. This goal has led to substantial research into how psychopathology symptoms relate to large-scale brain systems. However, these efforts have not yet resulted in practical biomarkers used in clinical practice. One reason for this underwhelming progress may be that many study designs focus on increasing sample size instead of collecting additional data within each individual. This focus limits the reliability and predictive validity of brain and behavioral measures in any one person. As biomarkers exist at the level of individuals, an increased focus on validating them within individuals is warranted. We argue that personalized models, estimated from extensive data collection within individuals, can address these concerns. We review evidence from two, thus far separate, lines of research on personalized models of (1) psychopathology symptoms and (2) fMRI measures of brain networks. We close by proposing approaches uniting personalized models across both domains to improve biomarker research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.