Evidence map›Paper›PMID 37267956›Full record

ArticleCell metabolism2023

Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood.

Lin Lin, Kwang-Mook Jung, Hye-Lim Lee, Johnny Le, Georgia Colleluori, Courtney Wood, Francesca Palese, Erica Squire, Jade Ramirez, Shiqi Su and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Adolescent ΔPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026
    Review
  4. Adolescent exposure to Δ9-tetrahydrocannabinol impairs testicular function in young adult male mice.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Distinct Adipocyte Responses to ΔInternational journal of molecular sciences · 2025
    Article
  10. Hepatic CB1 receptor signaling triggers GMetabolism: clinical and experimental · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Lin LinDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Kwang-Mook JungDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Hye-Lim LeeDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Johnny LeDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Georgia ColleluoriDepartment of Clinical and Experimental Medicine, Center of Obesity, Marche Polytechnic University, Ancona 600126, Italy.
Courtney WoodDepartment of Biomedical Sciences, University of California, Riverside, Riverside, CA 92697, USA.
Francesca PaleseDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Erica SquireDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Jade RamirezDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Shiqi SuDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Alexa TorrensDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Yannick FotioDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA.
Lingyi TangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Clinton YuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Qin YangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Lan HuangDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA.
Nicholas DiPatrizioDepartment of Biomedical Sciences, University of California, Riverside, Riverside, CA 92697, USA.
Cholsoon JangDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA.
Saverio CintiDepartment of Clinical and Experimental Medicine, Center of Obesity, Marche Polytechnic University, Ancona 600126, Italy.
Daniele PiomelliDepartment of Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92697, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: piomelli@hs.uci.edu.
University of California, Irvine · USMarche Polytechnic University · ITUniversity of California, Riverside · US

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Faizy Ahmed · 2018 to 2026
$18.2M
Proteomics of the Proteasome Interacting NetworksR01GM074830 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUANG, LAN · 2005 to 2022
$6.1M
Optimization and preclinical development of FAAH inhibitors for smoking cessationDP1DA031387 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI PIOMELLI, DANIELE · 2010 to 2014
$3.7M
Epigenetic Regulation of Mitochondrial Homeostasis and Energy MetabolismR01DK121146 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI Qin Yang · 2019 to 2026
$3.5M
Supplement: Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome SystemR35GM145249 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Lan Huang · 2022 to 2026
$3.2M
Elucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0M
NIAAA NIH HHS R01 AA029124NIDA NIH HHS DP1 DA031387NIDA NIH HHS P50 DA044118NIDDK NIH HHS R01 DK121146NIGMS NIH HHS R01 GM074830NIGMS NIH HHS R35 GM145249
6 · The paper itself

Abstract

One of cannabis' most iconic effects is the stimulation of hedonic high-calorie eating-the "munchies"-yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use of the drug often begins. We found that daily low-dose administration of cannabis' intoxicating constituent, Δ

Indexed as

DronabinolObesityAdiposityAnimalsEnergy IntakeHomeostasisMaleMiceDronabinol2-arachidonoylglyceroladipocyteanandamidecannabisendocannabinoids

Identifiers

PMID37267956
PMCPMC10524841
OpenAlexW4379057608

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.