Evidence map›Paper›PMID 37267917›Full record

ArticleCell stem cell2023

Systematic dissection of coordinated stromal remodeling identifies Sox10

Shawn M Sarkaria, Junsong Zhou, Suying Bao, Wenqi Zhao, Yinshan Fang, Jianwen Que, Govind Bhagat, Chaolin Zhang, Lei Ding

Open access · greenAbstract read
In one paragraph

Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Deep imaging of LepRBone research · 2025
    Article
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  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shawn M SarkariaColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Hematology and Medical Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Junsong ZhouColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Suying BaoDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wenqi ZhaoColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yinshan FangDivision of Digestive and Liver Diseases, Columbia Center for Human Development, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jianwen QueDivision of Digestive and Liver Diseases, Columbia Center for Human Development, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Govind BhagatDivision of Hematopathology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chaolin ZhangDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Lei DingColumbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: ld2567@cumc.columbia.edu.
Columbia University Irving Medical Center · USColumbia University · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Molecular Oncology Training ProgramT32CA203703 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Katherine D Crew, DAWN HERSHMAN · 2016 to 2026
$4.1M
Basal Progenitor Cells and Eosinophilic EsophagitisR01DK100342 · NIDDK · UNIVERSITY OF ROCHESTER · PI QUE, JIANWEN · 2014 to 2022
$3.3M
Understanding the role of stellate cells in the liver hematopoietic stem cell nicheR01HL153487 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2020 to 2024
$2.8M
Understanding and targeting bone marrow microenvironment in myelofibrosisR01HL155868 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2021 to 2024
$2.3M
Developing Next Generation Genetics for Understanding Hematopoietic Stem Cell BiologyR01GM146061 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DING, LEI, YAZAWA, MASAYUKI · 2022 to 2025
$2.0M
Regulation of hematopoietic stem cells and leukemia stem cells by thrombopoietinR01HL132074 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DING, LEI · 2016 to 2020
$2.0M
VEGF/KDR Signaling in Airway Epithelial Regeneration and DiseaseR01HL152293 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2021 to 2024
$2.0M
Signaling Mechanisms Promoting Barrett’s MetaplasiaR01DK120650 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2019 to 2022
$1.8M
NCI NIH HHS P30 CA013696NCI NIH HHS T32 CA203703NHLBI NIH HHS R01 HL132074NHLBI NIH HHS R01 HL152293NHLBI NIH HHS R01 HL153487NHLBI NIH HHS R01 HL155868NIDDK NIH HHS R01 DK100342NIDDK NIH HHS R01 DK120650NIGMS NIH HHS R01 GM146061
6 · The paper itself

Abstract

Remodeling of the tissue niche is often evident in diseases, yet, the stromal alterations and their contribution to pathogenesis are poorly characterized. Bone marrow fibrosis is a maladaptive feature of primary myelofibrosis (PMF). We performed lineage tracing and found that most collagen-expressing myofibroblasts were derived from leptin-receptor-positive (LepR

Indexed as

Primary MyelofibrosisBone MarrowEndothelial CellsHumansNeurogliaSOXE Transcription FactorsZinc Finger Protein GLI1SOX10 protein, humanSOXE Transcription FactorsZinc Finger Protein GLI1Gli1glial cellshematopoietic stem cellsLepRlineage tracingmesenchymal stromal cellsmicroenvironmental nichemyelofibrosissingle-cell RNA sequencing

Identifiers

PMID37267917
PMCPMC10240254
OpenAlexW4379015896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.