Evidence map›Paper›PMID 37267609›Full record

SynthesisInternational braz j urol : official journal of the Brazilian Society of Urology

Novel minimally invasive treatments for lower urinary tract symptoms: a systematic review and network meta-analysis.

Robertus Arnoldus Antonius van Kollenburg, Luigi Antonio Maria Johannes Gerardus van Riel, Daniel Martijn de Bruin, Theodorus Maria de Rijke, Jorg Reinier Oddens

Open access · diamondAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Review
  5. Article
  6. Article
  7. Review
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  10. A new option in the treatment of erectile dysfunction highligheted in International Brazilian Journal of Urology.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Robertus Arnoldus Antonius van KollenburgDepartment of Urology, Amsterdam UMC, University of Amsterdam, Biomedical Engineering and Physics, Netherlands.
Luigi Antonio Maria Johannes Gerardus van RielDepartment of Urology, Amsterdam UMC, University of Amsterdam, Biomedical Engineering and Physics, Netherlands.
Daniel Martijn de BruinDepartment of Urology, Amsterdam UMC, University of Amsterdam, Biomedical Engineering and Physics, Netherlands.
Theodorus Maria de RijkeDepartment of Urology, Amsterdam UMC, University of Amsterdam, Biomedical Engineering and Physics, Netherlands.
Jorg Reinier OddensDepartment of Urology, Amsterdam UMC, University of Amsterdam, Biomedical Engineering and Physics, Netherlands.
Amsterdam University College · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo review and compare the effectivity of novel minimally invasive treatments (MITs) to transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms (LUTS) in men.

methodsMedline, Embase, and Cochrane databases were searched from January 2010 to December 2022 for randomized controlled trials (RCTs) evaluating MITs, compared to TURP or sham, in men with LUTS. Studies were assessed by risk of bias tool, and evidence by GRADE. Functional outcomes by means of uroflowmetry and IPSS were the primary outcomes, safety and sexual function were secondary outcomes. As part of this review, a network meta-analysis (NMA) was conducted. MITs were ranked based on functional outcome improvement probability.

resultsIn total, 10 RCTs were included, evaluating aquablation, prostatic urethral lift, prostatic artery embolization (PAE), convective water vapor thermal treatment or temporary implantable nitinol device. All MITs showed a better safety profile compared to TURP. Functional outcome improvement following aquablation were comparable to TURP. In the NMA, aquablation was ranked highest, PAE followed with the second highest probability to improve functional outcomes. Other novel MITs resulted in worse functional outcomes compared to TURP. Level of evidence was low to very low.

conclusionsFive MITs for treatment of LUTS were identified. Aquablation is likely to result in functional outcomes most comparable to TURP. Second in ranking was PAE, a technique that does not require general or spinal anesthesia. MITs have a better safety profile compared to TURP. However, due to high study heterogeneity, results should be interpreted with caution.

Indexed as

Lower Urinary Tract SymptomsProstatic HyperplasiaTransurethral Resection of ProstateHumansMaleProstateTreatment OutcomeMinimally Invasive Surgical ProceduresProstateSystematic Review [Publication Type]

Identifiers

PMID37267609
PMCPMC10482440
OpenAlexW4379197666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.