Evidence map›Paper›PMID 37267298›Full record

ArticleChemMedChem2023

Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1.

Hanfei Wang, Robert Gaston, Kh Tanvir Ahmed, Gregory B Dudley, Amy M Barrios

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Inhibition of PHPT1 by phenylarsonic acids.Dalton transactions (Cambridge, England : 2003) · 2026
    Article
  2. Histidine Phosphorylation: Protein Kinases and Phosphatases.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hanfei WangDepartment of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, UT, 84112, USA.
Robert GastonDepartment of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Kh Tanvir AhmedDepartment of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Gregory B DudleyDepartment of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Amy M BarriosDepartment of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, UT, 84112, USA.ORCID 0000-0003-2739-9261
West Virginia University · USUniversity of Utah · US

Funding

Chemical synthesis of illudalic acid analogs for stimulant use disorderR15DA056843 · NIDA · WEST VIRGINIA UNIVERSITY · PI DUDLEY, GREGORY B · 2022 to 2022
$380k
NIDA NIH HHS R15 DA056843
6 · The paper itself

Abstract

PHPT1 is a protein histidine phosphatase that has been implicated in several disease pathways, but the chemical tools necessary to study the biological roles of this enzyme and investigate its utility as a therapeutic target have yet to be developed. To this end, the discovery of PHPT1 inhibitors is an area of significant interest. Here, we report an investigation of illudalic acid and illudalic acid analog-based inhibition of PHPT1 activity. Four of the seven analogs investigated had IC

Indexed as

Biological ProductsHistidineCoumarinsCysteinePhosphoric Monoester HydrolasesBiological ProductsCoumarinsCysteineHistidineilludalic acidPhosphoric Monoester Hydrolasesenzymeshistidineinhibitorsphosphatase

Identifiers

PMID37267298
PMCPMC10443188
OpenAlexW4379193237

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.